Tetramethylammonium

CAS Number 51-92-3
Molecular Formula C4H12N
Molecular Weight 74.146 g/mol
InChI Key QEMXHQIAXOOASZ-UHFFFAOYSA-N
LogP -2.41
Synonyms
  • Tetramethylammonium
  • N,N,N-Trimethylmethanaminium
  • Methanaminium, N,N,N-trimethyl-
  • 51-92-3

Applications:


Separation of Quaternary Amines
Primesep C separates a mixture of quaternary amines by a combination of cation exchange, complex formation, and hydrophic interactions. Methyltriethylammonium, tetraethylammonium, and tetramethylammonium cations as well as bromide counter ion are separated on a short 50 mm column. The separation uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and triethylamine acetate with evaporative light scattering detection (ELSD).

Condition

Column Primesep C, 4.6x50 mm
Mobile Phase MeCN/H2O
Buffer TEA acetate
Flow Rate 1.0 ml/min
Detection ELSD
 

Description

Class of Compounds Quaternary Amines, Ionizable, Hormone
Analyzing Compounds Methyltriethylammonium, tetraethylammonium, Tetramethylammonium
 

Application Analytes:

Bromide
Methyltriethylammonium Bromide
Quaternary Amines
Tetraethylammonium
Tetramethylammonium

Separation of Sodium, Tetramethylammonium and Tetrabutylammonium on Primesep 200 Column
chr_300.gif chr_301.gif Hydrophilic and hydrophobic quaternary amines, along with sodium ion, were separated by mixed-mode chromatography on a Primesep 200 column. Mechanism of retention for sodium and tetramethylammonium ions is cation exchange, while the tetrabutylammonium ion is retained by combination of reversed-phase and cation-exchange mechanisms. All three compounds are not UV-active and monitoring is done by ELSD/CAD.

Condition

Column Primesep 200,  4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmAc pH4.0
Flow Rate 1.0 ml/min
Detection ELSD
 

Description

Class of Compounds Ions,  Hydrophilic, Ionizable, Quaternary amines
Analyzing Compounds Sodium, Chloride, Tetramethylammonium,  Tetrabutylammonium


Application Analytes:

Sodium
Tetrabutylammonium
Tetramethylammonium

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