Amlodipine besylate

Amlodipine besylate structural formula

UV Spectra of Amlodipine

UV Spectra of Amlodipine

CAS Number 111470-99-6
Molecular Formula C26H31ClN2O8S
Molecular Weight 567.050 g/mol
InChI Key ZPBWCRDSRKPIDG-UHFFFAOYSA-N
LogP 3.30
Synonyms
  • Amlodipine besylate
  • Benzenesulfonic acid--3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (1/1)
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, benzenesulfonate (1:1)
  • 111470-99-6
  • Amlodipine benzenesulfonate
  • Amlodipine besilate
  • UK 48340-26
  • Amdepin
  • Amdipin
  • Amlodin
  • Amlogard
  • Amlopin
  • Amlosyn
  • Antacal
  • Astudar
  • Cardiorex
  • Cordarene
  • Monopina
  • Myodura
  • Norlopin
  • Norvask
  • Tensivask
  • UNII-864V2Q084H

Applications:


HPLC Method for Analysis of Azor
9222  

Condition

Column Primesep 200, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 30/65%
Buffer Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm
 

Application Analytes:

Amlodipine besylate
Azor
Olmesartan medoxomil

Separation of Amlodipine besylate on Newcrom R1 HPLC column

Amlodipine besylate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Amlodipine besylate on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Amlodipine besylate

HPLC Determination of Amlodipine in Norvasc Tablets
HPLC Determination of Amlodipine besylate in Norvasc Tablets  _1000  

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Amlodipine, Olmesartan medoxomil

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 60/40%
Buffer H2SO4 - 0.1 %
Flow Rate 1.0 ml/min
Detection UV, 238 nm
 

Description

Class of Compounds Drug, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Amlodipine (Norvasc)
 

Application Analytes:

Amlodipine besylate