Atenolol

CAS Number 29122-68-7
Molecular Formula C14H22N2O3
Molecular Weight 266.342 g/mol
InChI Key METKIMKYRPQLGS-UHFFFAOYSA-N
LogP 0.16
Synonyms
  • Atenolol
  • 2-(4-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • 29122-68-7
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • (.+-.)-Atenolol
  • (RS)-Atenolol
  • 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • Acetamide, 2-[p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]-
  • Anselol
  • Antipressan
  • Apo-Atenolol
  • Atcardil
  • Atecard
  • AteHexal
  • Atenblock
  • Atendol
  • Atereal
  • Atolmin
  • Betablok
  • Betacard
  • Blokium
  • Catenol
  • Catenolol
  • Coratol
  • Corotenol
  • Cuxanorm
  • DL-Atenolol
  • Duraatenolol
  • Evitocor
  • Farnormin
  • Felo-Bits
  • Hypoten
  • Ibinolo
  • Internolol
  • Lotenal
  • Myocord
  • Normalol
  • Normiten
  • Novaten
  • Premorine
  • Prenolol
  • Prenormine
  • Seles Beta
  • Selobloc
  • Stermin
  • Tenidon
  • Teno-basan
  • Tenoblock
  • Tenolin
  • Tenolol
  • Tenoprin
  • Tenordin
  • Tenormin
  • Tenormine
  • Tensimin
  • Ternomin
  • Vascoten
  • Vericordin
  • Wesipin
  • BRN 2739235
  • 1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol
  • EINECS 249-451-7
  • Tenobloc
  • Atenol Gador
  • Atenol-Mepha
  • Blocotenol
  • 2-(4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl)acetamid
  • Atenololum
  • UNII-50VV3VW0TI
  • EINECS 262-544-7
  • 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide
  • Aircrit
  • Alinor
  • Altol
  • Atenet
  • Ateni
  • Atenil
  • Atenol 1A pharma
  • Atenol AL
  • Atenol Atid
  • Atenol Cophar
  • Atenol Fecofar
  • Atenol GNR
  • Atenol Gador
  • Atenol Genericon
  • Atenol Heumann
  • Atenol MSD
  • Atenol NM Pharma
  • Atenol Nordic
  • Atenol PB
  • Atenol Quesada
  • Atenol Stada
  • Atenol Tika
  • Atenol Trom
  • Atenol acis
  • Atenol ct
  • Atenol von ct
  • Atenol-Mepha
  • Atenol-Wolff
  • Atenol-ratiopharm
  • Atenolin
  • Atenolol (JAN/USP)
  • Atenolol [USAN:BAN:INN:JAN]
  • Atenololum [INN-Latin]
  • Atenomel
  • Aterol
  • Betasyn
  • Betatop Ge
  • Blocotenol
  • Cardaxen
  • Cardiopress
  • Duratenol
  • Hipres
  • Jenatenol
  • Juvental
  • Lo-ten
  • Loten
  • Myocord
  • Noten
  • Oraday
  • Ormidol
  • Panapres
  • Plenacor
  • Prinorm
  • Scheinpharm Atenol
  • Serten
  • Servitenol
  • Tenobloc
  • Tenoretic
  • Tenormine [French]
  • Tredol
  • Unibloc
  • Uniloc
  • Xaten

Applications:


HPLC Separation of Atenolol on Legacy L1 Column
Atenolol is a selective beta receptor antagonist, a drug belonging to beta blockers. The USP method was reproduced on the L1 column. This method can be used for the analysis of atenolol by reversed-phase chromatography on a typical C18 HPLC column. Column and method can be used for other drug substances, intermediates and impurities which need to be analyzed according to the United States Pharmacopeia. Application Notes: Atenolol is a beta blocker used to treat heart disease as well as thyroid disorders and alcohol withdrawal. The USP HPLC method for the separation of atenolol was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer Octanesulfonic Acid, Sulfuric Acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Beta blocker, Hydrophobic, Ionizable
Analyzing Compounds Atenolol
 

Application Analytes:

Atenolol

HPLC Method for Analysis of Atenolol
45

Atenolol a cardioselective beta-1 adrenergic blocker as well as a synthetic isopropylamino-propanol derivative. It belongs to a class of drugs known as beta blockers and is used to treat high blood pressure (hypertension). Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Meclizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Application Analytes:

Atenolol

Application USP Methods for the Analysis of Atenolol using the Legacy L1 Column
Application USP Methods for the Analysis of Atenolol using the Legacy L1 Column

Application Analytes:

Atenolol