Atropine

Atropine structural formula

CAS Number51-55-8
Molecular FormulaC17H23NO3
Molecular Weight289.375
InChI KeyRKUNBYITZUJHSG-SPUOUPEWSA-N
LogP1.83
Synonyms
  • Atropine
  • (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • 51-55-8
  • Benzeneacetic acid, ?-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • (.+-.)-Atropine
  • (.+-.)-Hyoscyamine
  • 1?H,5?H-Tropan-3?-ol
  • Atropin
  • atropina
  • Benzeneacetic acid, ?-(hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(.+-.)-
  • Benzeneacetic acid, ?-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-
  • DL-Hyoscyamine
  • dl-Tropyl tropate
  • Tropine (.+-.)-tropate
  • Tropine tropate
  • Atropin-flexiolen
  • Atropinol
  • Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-
  • EINECS 200-104-8
  • Eyesules
  • alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
  • Isopto-atropine
  • 2-Phenylhydracrylic acid 3-alpha-tropanyl ester
  • DL-Tropanyl 2-hydroxy-1-phenylpropionate
  • Tropic acid, ester with tropine
  • Tropic acid, 3-alpha-tropanyl ester
  • (+,-)-Tropyl tropate
  • Troyl tropate
  • beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester
  • beta-Phenyl-gamma-oxypropionsaure-tropyl-ester
  • UNII-7C0697DR9I
  • (+-)-atropine
  • (+-)-hyoscyamine
  • (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • 3-hydroxy-2-phenyl-propionic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester
  • 3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester
  • 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
  • 8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
  • [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
  • dl-tropyltropate
  • tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
  • 78597-12-3

Applications:

HPLC Separation of Mixture of Atropine, Atrolactic Acid and Pralidoxime Chloride

April 15, 2019

 

Condition

Column Primesep 200, 4.6×150 mm, 3 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer Gradient H3PO4 – 0.1-0.3%, 10 min
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description

Class of Compounds
Drug, Acid, Base, Hydrophilic, Hydrophobic, Ionizable, Vitamin, Supplements
Analyzing Compounds Atropine, Atrolactic Acid, Pralidoxime Chloride

 

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Atrolactic Acid
Atropine
Pralidoxime Chloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of Atropine on Primesep 200 Column

April 5, 2019

 

Condition

Column Primesep 200, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer H2SO4 – 0.1 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description

Class of Compounds
Drug, Basic, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Atropine

 

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Atropine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Atropine on Newcrom R1 HPLC column

February 16, 2018
Separation of Atropine on Newcrom C18 HPLC column

Atropine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Atropine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.