Benzoic anhydride

Benzoic anhydride structural formula

CAS Number93-97-0
Molecular FormulaC14H10O3
Molecular Weight226.232
InChI KeyCHIHQLCVLOXUJW-UHFFFAOYSA-N
LogP2.26
Synonyms
  • Benzoic anhydride
  • 93-97-0
  • Benzoic acid, anhydride
  • anhidrido benzoico
  • Anhydride benzoique
  • Benzoesaureanhydrid
  • Benzoic acid, 1,1'-anhydride
  • Benzoyl anhydride
  • Benzoyl benzoate
  • NSC 37116
  • Benzoylbenzoate
  • EINECS 202-291-1
  • UNII-9K7X34FOV2
  • Benzoesaeureanhydrid
  • phenyl anhydride

Applications:

HPLC Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride on Newcrom R1 Column

June 3, 2022

Separation type: Liquid Chromatography Reverse Phase.


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride

Acetic Anyhydride is a common reagent in organic synthesis, particularly in the acetylation of alcohols, amines, and aromatic rings. Benzyl Alcohol is a popular organic solvent and preservative used in topical drugs, cosmetics, and intravenous drugs. Benzoic Anhydride is the anhydride form of Benzoic Acid and a common reagent in organic synthesis. These 3 organic compounds can be separated and analyzed on a Newcrom R1 reverse-phase column using a simple gradient analytical method with a mobile phase consisting of just water and Acetonitrile (MeCN) (with no ionic modifier). This analysis method can be UV detected at 200 or 275 nm with high resolution and peak symmetry.

 

Condition

Column Newcrom R1, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 20-100%
Buffer No
Flow Rate 0.5 ml/min
Detection UV 200, 275nm

Description

Class of Compounds Acid, Hydrophilic
Analyzing Compounds Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Acetic anhydride
Benzoic anhydride
Benzyl alcohol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method For Analysis Of Benzoic Anhydride on Primesep S2 Column

February 1, 2022

Separation type: Liquid Chromatography HILIC


Benzoic Anhydride is a derivative of Benzoic acid and a common benzoylation agent used in the pharmaceutical industry and a common reagent for synthesizing benzoic esters. Benzoic Anhydride can be retained and analyzed on a mixed-mode Primesep S2 column with a mobile phase consisting of just Acetonitrile (MeCN) without water or a buffer. This analytical method can be UV detected at 210 nm with high resolution and peak symmetry.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoic Anhydride

Condition

Column Primesep S2, 4.6×250 mm, 5 µm, 100A
Mobile Phase MeCN- 100%
Buffer No
Flow Rate 1.0 ml/min
Detection UV 210 nm

Description

Class of Compounds Anhydride
Analyzing Compounds Benzoic Anhydride

 

Application Column

Primesep S2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Benzoic anhydride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of Benzoic Anhydride on Newcrom R1 Column

July 26, 2021

Separation type: Liquid Chromatography Reverse Phase.



 


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High Performance Liquid Chromatography (HPLC) Method for Analysis of  Benzoic Anhydride.




Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic anhydride is used as a benzoylating agent in the manufacture of pharmaceuticals, intermediates and dyes. Benzoic Anhydride can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN), water and detected by UV, ELSD, CAD or LC/MS.




Condition

Column Newcrom R1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 70%
Buffer No
Flow Rate 1.0 ml/min
Detection 275 nm

Description

Class of Compounds Hydrophobic
Analyzing Compounds Benzoic Anhydride

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Benzoic anhydride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Benzoic anhydride on Newcrom R1 HPLC column

February 16, 2018
Separation of Benzoic anhydride on Newcrom C18 HPLC column

Benzoic anhydride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Benzoic anhydride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.