| CAS Number | 94-36-0 |
|---|---|
| Molecular Formula | C14H10O4 |
| Molecular Weight | 242.230 |
| InChI Key | OMPJBNCRMGITSC-UHFFFAOYSA-N |
| LogP | 3.46 |
| Synonyms |
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Applications:
HPLC Determination of Benzoyl Peroxide on Newcrom R1 Column
July 19, 2021
Separation type: Liquid Chromatography Reverse Phase.
High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoyl peroxide.
Benzoyl peroxide is a commonly used topical treatment for mild acne medications because of its antibacterial, anti keratolytic, and comedolytic actions. It is converted to benzoic acid in the skin and primarily targets the pilosebaceous units. Benzoyl Peroxide can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN) and water. The analysis method can be UV detected at 260 nm.
| Column | Newcrom R1, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN – 80% |
| Buffer | No |
| Flow Rate | 1.0 ml/min |
| Detection | 235 nm |
| Class of Compounds | Hydrophobic |
| Analyzing Compounds | Benzoyl peroxide, Benzoic Acid, Hydrogen peroxide |
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select optionsHydrogen Peroxide
Separation of Benzoyl peroxide on Newcrom R1 HPLC column
February 16, 2018
Benzoyl peroxide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options