Benztropine methylsulfonate

Benztropine methylsulfonate structural formula

CAS Number132-17-2
Molecular FormulaC22H29NO4S
Molecular Weight403.541
InChI KeyCPFJLLXFNPCTDW-BWSPSPBFSA-N
LogP4.18
Synonyms
  • Benzatropine mesylate
  • Benztropine methanesulfonate
  • Benztropine methylsulfonate
  • Methanesulfonic acid--(1R,3r,5S)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane (1/1)
  • 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo), methanesulfonate (1:1)
  • 132-17-2
  • Cobrentin methanesulfonate
  • Cogentin
  • 3-alpha-(Diphenylmethoxy)-1-alpha-H, 5-alpha-H-tropane methanesulfonate
  • EINECS 205-048-8
  • NSC 169913
  • Tropine benzohydryl ether methanesulfonate
  • Benzatropine mesylate
  • UNII-WMJ8TL7510
  • (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane methanesulfonate
  • 3-diphenylmethoxytropane mesylate
  • 3-diphenylmethoxytropane methanesulfonate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane mesylate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane methanesulfonate
  • 3alpha-(diphenylmethoxy)tropane mesylate
  • 3alpha-(diphenylmethoxy)tropane methanesulfonate
  • 3endo-benzhydryloxytropane mesylate
  • 3endo-benzhydryloxytropane methanesulphonate
  • benzatropine methanesulfonate
  • benztropine mesilate
  • benztropine mesylate
  • benztropine methanesulfonate
  • tropine benzohydryl ether mesylate
  • tropine benzohydryl ether methanesulphonate

Applications:

HPLC Method for Analysis of Benztropine mesylate on Primesep SB Column

April 29, 2019

HPLC Method for Benztropine methylsulfonate on Primesep SB by SIELC Technologies

Benztropine mesylate

High Performance Liquid Chromatography (HPLC) Method for Analysis of Benztropine methylsulfonate.

Benztropine is a medical drug used in treatment of patients with Parkinson’s disease. It works as an acetylcholine blocker decreasing muscle stiffness. Benztropine can be retained in HPLC on Primesep SB mixed-mode column by hydrophobic and anion-exchange properties. The isocratic method uses a mobile phase of acetonitrile (ACN) and water with sulfuric acid buffer and UV detection at 220nm.

Condition
Column Primesep SB, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 25/75%
Buffer H2SO4 – 0.1 %
Flow Rate 1.0 ml/min
Detection UV, 220 nm

 

Description
Class of Compounds
 Drug, Basic,  Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Benztropine methylsulfonate

 

Application Column

Primesep SB

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Benztropine methylsulfonate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Benztropine methylsulfonate on Newcrom R1 HPLC column

February 16, 2018
Separation of Benztropine methylsulfonate on Newcrom C18 HPLC column

Benztropine methylsulfonate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Benztropine methylsulfonate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.