Benztropine methylsulfonate

CAS Number 132-17-2
Molecular Formula C22H29NO4S
Molecular Weight 403.541 g/mol
InChI Key CPFJLLXFNPCTDW-BWSPSPBFSA-N
LogP 4.18
Synonyms
  • Benzatropine mesylate
  • Benztropine methanesulfonate
  • Benztropine methylsulfonate
  • Methanesulfonic acid--(1R,3r,5S)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane (1/1)
  • 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo), methanesulfonate (1:1)
  • 132-17-2
  • Cobrentin methanesulfonate
  • Cogentin
  • 3-alpha-(Diphenylmethoxy)-1-alpha-H, 5-alpha-H-tropane methanesulfonate
  • EINECS 205-048-8
  • NSC 169913
  • Tropine benzohydryl ether methanesulfonate
  • Benzatropine mesylate
  • UNII-WMJ8TL7510
  • (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane methanesulfonate
  • 3-diphenylmethoxytropane mesylate
  • 3-diphenylmethoxytropane methanesulfonate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane mesylate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane methanesulfonate
  • 3alpha-(diphenylmethoxy)tropane mesylate
  • 3alpha-(diphenylmethoxy)tropane methanesulfonate
  • 3endo-benzhydryloxytropane mesylate
  • 3endo-benzhydryloxytropane methanesulphonate
  • benzatropine methanesulfonate
  • benztropine mesilate
  • benztropine mesylate
  • benztropine methanesulfonate
  • tropine benzohydryl ether mesylate
  • tropine benzohydryl ether methanesulphonate

Applications:


Separation of Benztropine methylsulfonate on Newcrom R1 HPLC column

Benztropine methylsulfonate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Benztropine methylsulfonate on Newcrom C18 HPLC column
Newcrom R1

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Application Analytes:

Benztropine methylsulfonate

HPLC Method for Analysis of Benztropine mesylate on Primesep SB Column
Benztropine mesylate    

Condition

Column Primesep SB, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 25/75%
Buffer H2SO4 - 0.1 %
Flow Rate 1.0 ml/min
Detection UV, 220 nm
 

Description

Class of Compounds Drug, Basic,  Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Benztropine mesylate
 

Application Analytes:

Benztropine methylsulfonate