Benztropine methylsulfonate

Benztropine methylsulfonate structural formula

CAS Number 132-17-2
Molecular Formula C22H29NO4S
Molecular Weight 403.541 g/mol
LogP 4.18
  • Benzatropine mesylate
  • Benztropine methanesulfonate
  • Benztropine methylsulfonate
  • Methanesulfonic acid--(1R,3r,5S)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane (1/1)
  • 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo), methanesulfonate (1:1)
  • 132-17-2
  • Cobrentin methanesulfonate
  • Cogentin
  • 3-alpha-(Diphenylmethoxy)-1-alpha-H, 5-alpha-H-tropane methanesulfonate
  • EINECS 205-048-8
  • NSC 169913
  • Tropine benzohydryl ether methanesulfonate
  • Benzatropine mesylate
  • UNII-WMJ8TL7510
  • (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane methanesulfonate
  • 3-diphenylmethoxytropane mesylate
  • 3-diphenylmethoxytropane methanesulfonate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane mesylate
  • 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane methanesulfonate
  • 3alpha-(diphenylmethoxy)tropane mesylate
  • 3alpha-(diphenylmethoxy)tropane methanesulfonate
  • 3endo-benzhydryloxytropane mesylate
  • 3endo-benzhydryloxytropane methanesulphonate
  • benzatropine methanesulfonate
  • benztropine mesilate
  • benztropine mesylate
  • benztropine methanesulfonate
  • tropine benzohydryl ether mesylate
  • tropine benzohydryl ether methanesulphonate


Separation of Benztropine methylsulfonate on Newcrom R1 HPLC column

Benztropine methylsulfonate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Benztropine methylsulfonate on Newcrom C18 HPLC column
Newcrom R1

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Application Analytes:

Benztropine methylsulfonate

HPLC Method for Analysis of Benztropine mesylate on Primesep SB Column
Benztropine mesylate Benztropine is a medical drug used in treatment of patients with Parkinson’s disease. It works as an acetylcholine blocker decreasing muscle stiffness. Benztropine can be retained in HPLC on Primesep SB mixed-mode column by hydrophobic and anion-exchange properties. The isocratic method uses a mobile phase of acetonitrile (ACN) and water with sulfuric acid buffer and UV detection at 220nm.


Column Primesep SB, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 25/75%
Buffer H2SO4 - 0.1 %
Flow Rate 1.0 ml/min
Detection UV, 220 nm


Class of Compounds Drug, Basic,  Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Benztropine mesylate

Application Analytes:

Benztropine methylsulfonate

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