| CAS Number | 83881-51-0 |
|---|---|
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.890 g/mol |
| InChI Key | ZKLPARSLTMPFCP-UHFFFAOYSA-N |
| LogP | 1.70 |
| Synonyms |
|
Applications:
HPLC Method for Analysis of Cetirizine
Cetirizine is a member of the diphenylmethylpiperazine group of antihistamines and it contains L- and D-stereoisomers. The drug is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist. In general use, it treatments of hay fever, allergy symptoms (crying, itching, sneezing, etc.), and angioedema. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Cetirizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
| Column | Primesep 200, 3.2x100 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN - 5-50% |
| Buffer | Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds | Drug, Acid, Hydrophilic, Ionizable, |
| Analyzing Compounds | Cetirizine |
Application Analytes:
Cetirizine
