Cetirizine

CAS Number 83881-51-0
Molecular Formula C21H25ClN2O3
Molecular Weight 388.890 g/mol
InChI Key ZKLPARSLTMPFCP-UHFFFAOYSA-N
LogP 1.70
Synonyms
  • Cetirizine
  • (2-{4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
  • Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • 83881-51-0
  • Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid
  • Hitrizin Film Tablet
  • Cetirizina
  • Cetirizinum
  • UNII-YO7261ME24
  • Cetirizin

Applications:


HPLC Method for Analysis of Cetirizine
Chr_1040 Cetirizine is a member of the diphenylmethylpiperazine group of antihistamines and it contains L- and D-stereoisomers. The drug is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist. In general use, it treatments of hay fever, allergy symptoms (crying, itching, sneezing, etc.), and angioedema. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Cetirizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Condition

Column Primesep 200, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 5-50%
Buffer Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm
   

Description

Class of Compounds Drug,  Acid, Hydrophilic, Ionizable,
Analyzing Compounds Cetirizine


Application Analytes:

Cetirizine