Cocaine

Cocaine structural formula

CAS Number50-36-2
Molecular FormulaC17H21NO4
Molecular Weight303.358
InChI KeyZPUCINDJVBIVPJ-PFSRBDOWSA-N
LogP2.30
Synonyms
  • Cocaine
  • Methyl (2R,3S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
  • 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (2R,3S)-
  • 50-36-2
  • 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R,2R,3S,5S)-
  • (-)-Cocaine
  • (R)-Cocaine
  • 2β-Carbomethoxy-3β-(benzoyloxy)tropane
  • 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, [1R-(exo,exo)]-
  • Benzoylmethylecgonine
  • cocaina
  • l-Cocaine
  • Neurocaine
  • C Carrie
  • 3-(Benzoyloxy)-8-methyl-8-azabicyclo-(3.2.1)octane-2-carboxylic acid methyl ether
  • Bernies
  • 2beta-Carbomethoxy-3beta-benzoxytropane
  • 2-beta-Carbomethoxy-3-beta-benzoxytropane
  • Cocaine, l-
  • Dama blanca
  • EINECS 200-032-7
  • Eritroxilina
  • Erytroxylin
  • Happy trails
  • 3beta-Hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylic acid methyl ester benzoate
  • Kokayeen
  • (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate
  • Methyl Benzoylecgonine
  • Nose candy
  • Pimp's drug
  • Star dust
  • 3-Tropanylbenzoate-2-carboxylic acid methyl ester
  • White girl or lady
  • Crack cocaine
  • UNII-I5Y540LHVR

Applications:

HPLC Method for Analysis of Cocaine

April 29, 2016

Chr_1041

Cocaine, also known as coke, is mostly used as a recreational drug. It is a strong stimulant. The drug’s most common appearance in powder form is a salt, usually cocaine hydrochloride. Due to Cocaine rapidly metabolizing in the body, so if it’s ingested/inhaled, its concentration in urine usually does not exceed 10% that of its principal metabolite, benzoylecgonine. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Cocaine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Condition

Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 5-50%
Buffer Gradient H3PO4 – 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

 

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable,
Analyzing Compounds Cocaine

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Cocaine

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.