1,5-Naphthalenedisulfonic Acid

CAS Number 81-04-9
Molecular Formula C10H8O6S2
Molecular Weight 288.291 g/mol
LogP -0.262
  • 1,5-Naphthalenedisulfonic acid
  • Naphthalene-1,5-disulfonic acid
  • 81-04-9
  • 4-11-00-00561
  • BRN 0619838
  • EINECS 201-317-9
  • 1,5-Naphthylene disulfonic acid
  • NSC 9588
  • UNII-E8FPK78470
  • Armstrong's acid
  • naphthalene-1,5-disulfonic acid
  • 46874-44-6


HILIC Retention of 1,5-Naphthalenedisulfonic Acid on Obelisc N Mixed-Mode HILIC Columns

Naphthalenedisulfonic acid is retained by anion-exchange mechanism on Obelisc N mixed-mode HILIC column. Retention time is controlled by amount of ion in the mobile phase. Method demonstrates very good peak shape and controllable retention. This mixed-mode approach can be used for quantitation of various sulfonic acid in different matrices. UV, ELSD or LC/MS can be used for quantitation.

Application Analytes:

1,5-Naphthalenedisulfonic Acid
Sulfonic Acid

HPLC Separation of Organic Acids in HILIC and Anion-Exclusion Mode on Primesep S2 Column
Organic acids were separated on a HILIC/cation-exchange column in HILIC/anion-exclusion mode. This column can be used for analysis of polar compounds in HILIC mode. If compounds are ionizable, additional mode of interaction can be added (cation-exchange or anion-exclusion).


Column Primesep S2, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 85/15%
Buffer AmAc pH 5.0 15 mM
Flow Rate 1.0 ml/min
Detection ELSD, 50C UV 250 nm


Class of Compounds Nucleosides,  Hydrophilic, Ionizable
Analyzing Compounds Toluenesulfonic acid, Naphthalenedisulfonic acid, 3.5 DHBA, Ascorbic acid,

Application Analytes:

1,5-Naphthalenedisulfonic Acid
3,5-Dihydroxybenzoic Acid
Ascorbic Acid
Organic Acids
p-Toluenesulfonic Acid (PTSA)