4-Aminosalicylic Acid

CAS Number 65-49-6
Molecular Formula C7H7NO3
Molecular Weight 153.137 g/mol
InChI Key WUBBRNOQWQTFEX-UHFFFAOYSA-N
LogP 0.89
Synonyms
  • Aminosalicylic acid
  • 4-Amino-2-hydroxybenzoic acid
  • Benzoic acid, 4-amino-2-hydroxy-
  • 65-49-6
  • 4-14-00-01967
  • Benzoic acid, 4-amino-2-hydroxy-
  • 2-Hydroxy-4-aminobenzoic acid
  • 3-Hydroxy-4-carboxyaniline
  • 4-Amino-2-hydroxybenzoic acid
  • 4-aminosalicylic acid
  • 4-Aminosalicylsaure
  • 4-Carboxy-3-hydroxyaniline
  • Acide 4-aminosalicylique
  • acido 4-aminosalicilico
  • Amino-PAS
  • Deapasil
  • Entepas
  • Gabbropas
  • Monopass
  • NSC 2083
  • NSC 211698
  • Pamacyl
  • p-Aminosalicylic acid
  • Pamisyl
  • Para-aminosalicylic acid
  • Paramycin
  • Para-Pas
  • Parasal
  • Parasalicil
  • Parasalindon
  • PAS (acid)
  • Pasalon
  • Pasnodia
  • Pasolac
  • Propasa
  • Rezipas
  • Salicylic acid, 4-amino-
  • Sanipirol-4
  • Aminopar
  • Aminosalyl
  • BRN 0473071
  • EINECS 200-613-5
  • Helipidyl
  • Hellipidyl
  • PAS (VAN)
  • Pascorbic
  • Pasdium
  • Paser Granules
  • Kyselina p-aminosalicylova
  • UNII-5B2658E0N2
  • PAS
  • Para-amino salicylic acid

Applications:


HPLC Separation of Isomers of Amino Salicylic Acid


4-Aminosalicylic acid (PAS) is an antibiotic used in treatment of tuberculosis. It is a polar amino acid with limited retention on traditional C18 (reversed-phase) columns. Other isomers of aminosalicylic acid exist, but the main impurity in PAS is 5-Aminosalicylic acid, which also serves as anti-inflammatory drug. Both compounds are isomers with similar empirical structure and properties. These two isomers were separated on a Primesep 100 column with UV, ELSD and LC/MS compatible mobile phase. Method can be used a generic approach for separation of isomers of basic and zwitter ionic compounds. Isomers are retained and separated based on reversed-phase and cation-exchange properties. Retention time is controlled by the amount of acetonitrile, buffer concentration and buffer pH. Buffer pH is affecting ionization of these two compounds and thus serves as a powerful tool to adjust selectivity of separation.



Application Analytes:

4-Aminosalicylic Acid
5-Aminosalicylic Acid