Albendazole

CAS Number 54965-21-8
Molecular Formula C12H15N3O2S
Molecular Weight 265.330 g/mol
InChI Key HXHWSAZORRCQMX-UHFFFAOYSA-N
LogP 3.07
Synonyms
  • Albendazole
  • Methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate
  • Carbamic acid, N-[5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
  • 54965-21-8
  • Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
  • [5-(propylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester
  • Albamelin
  • Albendazol
  • Albendol
  • Albenza
  • Alminth
  • Alzental
  • Andazol
  • Carbamic acid, N-[6-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
  • Eskazole
  • Exiptol
  • Haojing
  • Methyl 5-propylthio-2-benzimidazolecarbamate
  • NSC 220008
  • Valbazen
  • Vermitan
  • EINECS 259-414-7
  • Methyl 5-(propylthio)-2-benzimidazolecarbamate
  • (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
  • Bilutac
  • ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle
  • Albendazolum
  • UNII-F4216019LN
  • 5-(propylthio)-2-carbomethoxyaminobenzimidazole
  • O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate
  • Proftril
  • Valbazen
  • Zentel

Applications:


HPLC Separation of Tylosin and Albendazole


Tylosine is an antibiotic used in veterinary medicine. This sugar-based amino compound is found naturally in fermentation products. Presence of sugar moieties and amino group make it impossible to analyze this compound by reversed-phase HPLC with LC/MS compatible conditions. Mixed-mode chromatography allows to overcome this obstacle, and retain and analyze this and other aminoglycosides on an Obelisc R column. This column is suitable for analysis of aminosugars with several basic groups in the molecule (streptomycine, neomycin, amikasin, arbekasin, dibekasin, framycetin, kanamycin, gentamycin, verdomycin, astromycin, hydromycin, etc.). In case of several amino groups, higher buffer concentration and lower pH (3-3.5) are required in order to facilitate elution from the column. This method does not use ion-pairing reagent, and is designed to replace traditional reversed-phase columns and ion-pairing reagent methods. In this application, Albedazole is used as internal standard to quantify aminoglycoside.



Application Analytes:

Albendazole
Tylosin

HPLC Separation of Bendazoles on Primesep P Column



Eight bendazoles are separated on Primesep P HPLC column by combination of reverse phase and ion-exchange mechanisms. Primesep P column can be used when mixed-mode mechanisms, including pi-pi interactions, can benefit separation. HPLC column and method is compatible with all detection technique.



Application Analytes:

2-Aminosulphone Albendazole Metabolite
5-Hydroxy Thiabendazole
Albendazole
Cambendazole
Carbendazim
Fenbendazole
Mebendazole
Oxfendazole
Thiabendazole