Albuterol

CAS Number 18559-94-9
Molecular Formula C13H21NO3
Molecular Weight 239.316 g/mol
InChI Key NDAUXUAQIAJITI-UHFFFAOYSA-N
LogP 0.624
Synonyms
  • Albuterol
  • 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
  • 1,3-Benzenedimethanol, alpha1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-
  • 18559-94-9
  • Salbutamol
  • 1,3-Benzenedimethanol, α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-
  • (.+-.)-Albuterol
  • (.+-.)-Salbutamol
  • 1-(tert-Butylaminomethyl)-4-hydroxy-m-xylene-α1,α3-diol
  • 1,3-Benzenedimethanol,α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-
  • 2-(tert-Butylamino)-1-[(4-hydroxy-3-hydroxymethyl)phenyl]ethanol
  • 4-Hydroxy-3-(hydroxymethyl)-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
  • Airomir
  • dl-Albuterol
  • DL-N-tert-Butyl-2(4-hydroxy-3-hydroxymethylphenyl)2-hydroxyethylamine
  • dl-Salbutamol
  • Etinoline
  • m-Xylene α,α'-diol, α-[(tert-butylamino)methyl]-4-hydroxy-
  • m-Xylene-α,α'-diol, α1-[(tert-butylamino)methyl]-4-hydroxy-
  • Proventil HFA
  • Proventil Inhaler
  • Sabumol
  • Salamol EB
  • Saventol
  • Sultanol
  • Sultanol N
  • Ventalin Inhaler
  • Ventolin
  • Ventoline
  • α1-tert-Butylaminomethyl-4-hydroxy-m-xylene-α1,α3-diol
  • Aerolin
  • BRN 2213614
  • 2-(tert-Butylamino)-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol
  • alpha'-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol
  • EINECS 242-424-0
  • 4-Hydroxy-3-hydroxymethyl-alpha-((tert-butylamino)methyl)benzyl alcohol
  • m-Xylene-alpha,alpha'-diol, alpha-((tert-butylamino)methyl)-4-hydroxy-
  • 1-(tert-Butylaminomethyl)-4-hydroxy-m-xylene-alpha1,alpha3-diol
  • DL-N-tert-Butyl-2-(4-hydroxy-3-hydroxymethylphenyl)-2-hydroxyethylamine
  • Almotex
  • Alti-Salbutamol
  • Anebron
  • Arubendol-Salbutamol
  • Asmadil
  • Asmanil
  • Asmasal
  • Asmatol
  • Asmaven
  • Asmidon
  • Asmol Uni-Dose
  • Asthalin
  • Broncho-Spray
  • Broncovaleas
  • Bronter
  • Bugonol
  • Butamol
  • Buto-Asma
  • Butohaler
  • Butotal
  • Butovent
  • Buventol
  • Cobutolin
  • Dilatamol
  • Farcolin
  • Gerivent
  • Grafalin
  • Libretin
  • Medolin
  • Novosalmol
  • Parasma
  • Pneumolat
  • Respolin
  • Sabutal
  • Salamol
  • Salbetol
  • Salbron
  • Salbu-BASF
  • Salbu-Fatol
  • Salbuhexal
  • Salbulin
  • Sallbupp
  • Salbupur
  • Salbusian
  • Salbutalan
  • Salbutan
  • Salbutol
  • Salbuven
  • Salbuvent
  • Salmaplon
  • Salomol
  • Salvent
  • Servitamol
  • Suprasma
  • Theosal
  • Tobybron
  • Vencronyl
  • Ventamol
  • Ventilan
  • Ventiloboi
  • Zaperin
  • Volare albuterol HFA
  • Volare easi-breathe
  • Ventodisks
  • Salbutamolum
  • UNII-QF8SVZ843E
  • Vospire
  • Proventil

Applications:


HPLC Separation of Albuterol and Amoxicillin
Primesep 100 separates albuterol and amoxicillin with baseline resolution by a combination of cation-exchange, hydrophobic, and polar interactions. The mass spec (LC/MS) compatible separation uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) with UV detection at 210 nm.  

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 30/70%
Buffer TFA - 0.15%
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description

Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Albuterol,  Amoxicillin
 

Application Analytes:

Albuterol
Amoxicillin

USP Analysis of Albuterol Using a Legacy L1 Column
  Application Notes: Albuterol is a well known drug used to treat bronchospasms. Albuterol come in many different forms, ranging from nebulizer to tablets. Albuterol is an important drug in combatting breathing problems. The USP methods for albuterol dictate that albuterol should not contain less than 98.5% and no more than 101% calculated on a dried basis. The USP HPLC method for the separation of albuterol was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of USP. Application Columns: Legacy L1 C18 HPLC column Application compounds: Albuterol Mobile phase: Water with 1% acetic acid and 5mM hexane sulfonic acid and MeOH (60:40) Detection technique: UV Reference: USP35: NF30

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase Water with 1% Acetic  and 5 mM   Hexane sulfonic acid/ MeOH  ( 60-40)
Buffer Acetic Acid,  Hexane sulfonic acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Bronchodilator, Hydrophobic, Ionizable
Analyzing Compounds Albuterol
 

Application Analytes:

Albuterol