Alendronic Acid

CAS Number 66376-36-1
Molecular Formula C4H13NO7P2
Molecular Weight 249.096 g/mol
LogP -2.63
  • Alendronic Acid
  • (4-Amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
  • Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-
  • 66376-36-1
  • Alendronate
  • Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-
  • 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
  • (4-Amino-1-hydroxybutylidene)bisphosphonic acid
  • 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
  • Arendal
  • Acide alendronique
  • Acido alendronico
  • Acidum alendronicum
  • UNII-X1J18R4W8P
  • G-704650
  • MK-217


HPLC Separation of Alendronic, Ibandronic, Etidronic Acids

Dronic acids are bisphosphonates that differ in their alkyl chains. Alendronate (Fosamax) marketed alone is used for osteoporosis and other bone diseases. It is also combined with Vitamin C (Fosavance). A short, 50 mm Primesep SB column separates alendronic, ibandronic, and etidronic acids. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN), trifluoracetic acid (TFA) or ammonium formate and evaporative light scattering detection (ELSD) at 80°C.

Application Analytes:

Alendronic Acid
Etidronic Acid
Ibandronic Acid