Amikacin

CAS Number 37517-28-5
Molecular Formula C22H43N5O13
Molecular Weight 585.608 g/mol
InChI Key LKCWBDHBTVXHDL-RMDFUYIESA-N
LogP -4.09
Synonyms
  • Amikacin
  • (2S)-4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide
  • Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-
  • 37517-28-5
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-[6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
  • 1-N-[L-(-)-gamma-Amino-alpha-hydroxybutyryl]kanamycin A
  • Amikozit
  • Amukin
  • Arikace
  • BAY 41-6551
  • BAY 416651
  • BB-K 8
  • Potentox
  • Amicacin
  • Amikacillin
  • amikacina
  • amikacine
  • Antibiotic BB-K 8
  • D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1-6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1-4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-
  • D-Streptamine,O-3-amino-3-deoxy-α-D-glucopyranosyl-(1-6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1-4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
  • Lukadin
  • Amiglyde-V
  • Amikavet
  • 1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A
  • EINECS 253-538-5
  • Mikavir
  • NSC 177001
  • Amikacinum
  • UNII-84319SGC3C
  • Amikacin Inhalation Solution
  • O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine
  • 108914-65-4
  • 110660-81-6
  • 110660-83-8
  • 111319-93-8
  • 38859-32-4
  • 1079316-47-4

Applications:


Retention of Amikacin on Obelisc R Column


Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Most of aminoglycoside antibiotic are very polar compounds containing several amino groups and sugar fragments. Such compounds are not retained on reverse phase column without ion-pairing reagents. In this application Amikacin is retained on Obelisc R column without ion-pairing reagent. Retention is contributed to mixed-mode mechanism and can be adjusted by buffer pH and buffer concentration. Amount of organic modifier (acetonitrile, tetrahydrophuran, etc.) can be used for fine tuning and improvement of peak shape. Other amino sugars can be analyzed using mixed-mode stationary phases with ELSD, LC/MS and prep chromatography compatible mobile phases.

Application Analytes:

Amikacin