Amoxicillin

CAS Number	26787-78-0
Molecular Formula	C16H19N3O5S
Molecular Weight	365.400 g/mol
InChI Key	LSQZJLSUYDQPKJ-NJBDSQKTSA-N
LogP	0.87
Synonyms	Amoxicillin (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- 26787-78-0 p-Hydroxyampicillin (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-[D-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-[D-α-Amino-α-(4-hydroxyphenyl)acetamido]penicillanic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- [2S-[2alpha,5alpha,6beta(S)]]-6-[[Amino(4-hydroxyphenyl)acetyl amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2α,5α,6β(S)]]- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D- 6-[D-(-)-p-Hydroxy-α-aminobenzyl]penicillin 6-[D(-)-α-Amino-p-hydroxyphenylacetamido]penicillanic acid Abdimox Actimoxi Adbiotin Agerpen Alfamox Almodan Alphamox Amagesen Solutab Amocilline Amoclen Amo-flamsian Amoflux Amopenixin Amosine Amoxapen Amoxaren Amoxcillin Amoxi-basan Amoxibiotic amoxicilina Amoxicillin Chewable Tablets Amoxicilline Amoxidal Amoxiden Amoxidin Amoxihexal Amoxillin Amoxi-Mast Amoxipen Amoxipenil Amoxisol Amoxivan Amoxivet Amoxtrex Amoxycillin Amoxy-diolan Amoxypen Ampidroxyl Ampy-Penyl Anemolin Apitart Apo-Amoxi Aspenil Audumic Azillin Bactamox Betamox Bintamox Bioxidona Bioxyllin Bridopen Bristamox Cabermox Cemoxin Cilamox Clamoxyl Coamoxin Comoxyl D-(-)-α-Amino-p-hydroxybenzyl penicillin D-(α-Amino-p-hydroxybenzyl)penicillin D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid Damoxicil D-Amoxicillin Delacillin Draximox Efpenix Efpinex Eupensol Excillin Farconcil Fisamox Flemoxin Foxolin Fullcilina Gimalxina Gomcillin Gramidil Grinsil Grinsul Grunamox Helvamox Hiconcil Hidramox Histocillin Hosboral Ibiamox Ikamoxil Imacillin Imaxilin Intermox Isimoxin Izoltil Jerramcil Kamoxin Larocilin Larotid Majorpen Matasedrin Medimox Metafarma capsules Metifarma capsules Morgenxil Moxacin Moxaline Moxarin Moxilen Moxylin Moxypen Moxyvit Novabritine Novamoxin Novenzymin NSC 277174 Ospamox Pamocil Pamoxicillin Pasetocin Penamox Penbiosyn Penimox Piramox Polymox Protexillin Ranmoxy Ranoxyl Reloxyl Rhamoxilina Robamox Rocillin Ronemox Saltermox Samosillin Samthongcillin Sawacillin Sawamezin Sia-mox Sigmopen Sil-A-mox Simoxil Simplamox Specillin Superpeni Suprapen Suramox PM Teramoxyl Tolodina Triafamox Triamoxil Trilaxin Unicillin Velamox Vetomoxin Vetramox Virgoxillin Widecillin Yisulon Zamocillin Zamoxil Zerrsox D-(-)-alpha-Amino-p-hydroxybenzylpenicillin (-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid EINECS 248-003-8 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin Sawamox PM DisperMox Moxatag Amoxicillin pediatric Amoxicaps Amoxicillinum UNII-9EM05410Q9 6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid AX Amoxicillin Amoxicillin anhydrous alpha-amino-p-hydroxybenzylpenicillin amoxycilin 33911-69-2 71447-36-4 81030-75-3 1236363-38-4

Applications:

HPLC Separation of Albuterol and Amoxicillin

Primesep 100 separates albuterol and amoxicillin with baseline resolution by a combination of cation-exchange, hydrophobic, and polar interactions. The mass spec (LC/MS) compatible separation uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) with UV detection at 210 nm.

Condition
Column	Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O - 30/70%
Buffer	TFA - 0.15%
Flow Rate	1.0 ml/min
Detection	UV, 210 nm

Description
Class of Compounds	Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds	Albuterol, Amoxicillin

Albuterol
Amoxicillin

USP Method for the Analysis of Amoxicillin using the Legacy L1 Column

Application Notes: Amoxicillin is one of the most commonly prescribed antibiotics. It is often used for treating strep throat. According to USP methods, amoxicillin should not contain less than 900ug and no more than 1050ug of amoxicillin per mg. The USP HPLC method for the separation of amitriptyline was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS. Application Columns: Legacy L1 C18 HPLC column Application compounds: Amoxicillin Mobile phase: MeCN/50 mM dibasic sodium phosphate Detection technique: UV Source: USP35: NF30

Condition
Column	Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase	MeCN/50 mM NaH2PO4 pH 5.0 (4/96)
Buffer	NaH2PO4
Flow Rate	1.0 ml/min
Detection	UV, 230 nm

Description
Class of Compounds	Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds	Amoxicillin