Amoxicillin

Amoxicillin structural formula

CAS Number 26787-78-0
Molecular Formula C16H19N3O5S
Molecular Weight 365.400 g/mol
InChI Key LSQZJLSUYDQPKJ-NJBDSQKTSA-N
LogP 0.87
Synonyms
  • Amoxicillin
  • (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • 26787-78-0
  • p-Hydroxyampicillin
  • (2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 6-[D-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 6-[D-α-Amino-α-(4-hydroxyphenyl)acetamido]penicillanic acid
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • [2S-[2alpha,5alpha,6beta(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2α,5α,6β(S*)]]-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D-
  • 6-[D-(-)-p-Hydroxy-α-aminobenzyl]penicillin
  • 6-[D(-)-α-Amino-p-hydroxyphenylacetamido]penicillanic acid
  • Abdimox
  • Actimoxi
  • Adbiotin
  • Agerpen
  • Alfamox
  • Almodan
  • Alphamox
  • Amagesen Solutab
  • Amocilline
  • Amoclen
  • Amo-flamsian
  • Amoflux
  • Amopenixin
  • Amosine
  • Amoxapen
  • Amoxaren
  • Amoxcillin
  • Amoxi-basan
  • Amoxibiotic
  • amoxicilina
  • Amoxicillin Chewable Tablets
  • Amoxicilline
  • Amoxidal
  • Amoxiden
  • Amoxidin
  • Amoxihexal
  • Amoxillin
  • Amoxi-Mast
  • Amoxipen
  • Amoxipenil
  • Amoxisol
  • Amoxivan
  • Amoxivet
  • Amoxtrex
  • Amoxycillin
  • Amoxy-diolan
  • Amoxypen
  • Ampidroxyl
  • Ampy-Penyl
  • Anemolin
  • Apitart
  • Apo-Amoxi
  • Aspenil
  • Audumic
  • Azillin
  • Bactamox
  • Betamox
  • Bintamox
  • Bioxidona
  • Bioxyllin
  • Bridopen
  • Bristamox
  • Cabermox
  • Cemoxin
  • Cilamox
  • Clamoxyl
  • Coamoxin
  • Comoxyl
  • D-(-)-α-Amino-p-hydroxybenzyl penicillin
  • D-(α-Amino-p-hydroxybenzyl)penicillin
  • D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid
  • Damoxicil
  • D-Amoxicillin
  • Delacillin
  • Draximox
  • Efpenix
  • Efpinex
  • Eupensol
  • Excillin
  • Farconcil
  • Fisamox
  • Flemoxin
  • Foxolin
  • Fullcilina
  • Gimalxina
  • Gomcillin
  • Gramidil
  • Grinsil
  • Grinsul
  • Grunamox
  • Helvamox
  • Hiconcil
  • Hidramox
  • Histocillin
  • Hosboral
  • Ibiamox
  • Ikamoxil
  • Imacillin
  • Imaxilin
  • Intermox
  • Isimoxin
  • Izoltil
  • Jerramcil
  • Kamoxin
  • Larocilin
  • Larotid
  • Majorpen
  • Matasedrin
  • Medimox
  • Metafarma capsules
  • Metifarma capsules
  • Morgenxil
  • Moxacin
  • Moxaline
  • Moxarin
  • Moxilen
  • Moxylin
  • Moxypen
  • Moxyvit
  • Novabritine
  • Novamoxin
  • Novenzymin
  • NSC 277174
  • Ospamox
  • Pamocil
  • Pamoxicillin
  • Pasetocin
  • Penamox
  • Penbiosyn
  • Penimox
  • Piramox
  • Polymox
  • Protexillin
  • Ranmoxy
  • Ranoxyl
  • Reloxyl
  • Rhamoxilina
  • Robamox
  • Rocillin
  • Ronemox
  • Saltermox
  • Samosillin
  • Samthongcillin
  • Sawacillin
  • Sawamezin
  • Sia-mox
  • Sigmopen
  • Sil-A-mox
  • Simoxil
  • Simplamox
  • Specillin
  • Superpeni
  • Suprapen
  • Suramox PM
  • Teramoxyl
  • Tolodina
  • Triafamox
  • Triamoxil
  • Trilaxin
  • Unicillin
  • Velamox
  • Vetomoxin
  • Vetramox
  • Virgoxillin
  • Widecillin
  • Yisulon
  • Zamocillin
  • Zamoxil
  • Zerrsox
  • D-(-)-alpha-Amino-p-hydroxybenzylpenicillin
  • (-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid
  • 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid
  • EINECS 248-003-8
  • 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin
  • Sawamox PM
  • DisperMox
  • Moxatag
  • Amoxicillin pediatric
  • Amoxicaps
  • Amoxicillinum
  • UNII-9EM05410Q9
  • 6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid
  • AX
  • Amoxicillin
  • Amoxicillin anhydrous
  • alpha-amino-p-hydroxybenzylpenicillin
  • amoxycilin
  • 33911-69-2
  • 71447-36-4
  • 81030-75-3
  • 1236363-38-4

Applications:

HPLC Separation of Albuterol and Amoxicillin
Primesep 100 separates albuterol and amoxicillin with baseline resolution by a combination of cation-exchange, hydrophobic, and polar interactions. The mass spec (LC/MS) compatible separation uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) with UV detection at 210 nm.  

Condition
Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 30/70%
Buffer TFA - 0.15%
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description
Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Albuterol,  Amoxicillin
 
Application Analytes:

Albuterol
Amoxicillin
USP Method for the Analysis of Amoxicillin using the Legacy L1 Column
  Application Notes: Amoxicillin is one of the most commonly prescribed antibiotics. It is often used for treating strep throat. According to USP methods, amoxicillin should not contain less than 900ug and no more than 1050ug of amoxicillin per mg.  The USP HPLC method for the separation of amitriptyline was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS. Application Columns: Legacy L1 C18 HPLC column Application compounds: Amoxicillin Mobile phase: MeCN/50 mM dibasic sodium phosphate Detection technique: UV Source: USP35: NF30 

Condition
Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/50 mM NaH2PO4  pH 5.0 (4/96)
Buffer NaH2PO4
Flow Rate 1.0 ml/min
Detection UV, 230 nm
 

Description
Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Amoxicillin
 
Application Analytes:

Amoxicillin
HPLC Separation of β-Lactam Antibiotics on Primesep 100 Column
Separation type: Liquid Chromatography Mixed-mode

HPLC.cloud View on hplc.cloud



High Performance Liquid Chromatography (HPLC) Method for Analysis of Amoxicillin and Cephalexin. Both amoxicillin and cephalexin are beta-lactam antibiotics. Beta-lactam antibiotics contain a beta-lactam ring in their molecular structure. As a group, these drugs are active against many gram-positive, gram-negative and anaerobic organisms. Both compounds can be retained and baseline separated with an isocratic method in 30/70 Acetonitrile (ACN) and water mobile phase with a Sulfuric acid (H2SO4) buffer. UV detection at 250 nm.

Condition
Column Primesep 100, 4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA, H2SO4
Flow Rate 1.0 ml/min
Detection UV, 250 nm
 

Description
Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Cephalexin,  Amoxicillin
 
Application Analytes:

Amoxicillin
Amoxicillin hydrate (1:3)
Cephalexin