Chlorpheniramine

Chlorpheniramine structural formula

CAS Number 132-22-9
Molecular Formula C16H19ClN2
Molecular Weight 274.791 g/mol
InChI Key SOYKEARSMXGVTM-UHFFFAOYSA-N
LogP 3.38
Synonyms
  • Chlorpheniramine
  • 3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
  • 132-22-9
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
  • (.+-.)-Chloropheniramine
  • (.+-.)-Chlorpheniramine
  • 1-(p-Chlorophenyl)-1-(2'-pyridyl)-3-(N,N-dimethylamino)-propane
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 4-Chloropheniramine
  • Allergican
  • Chloropheniramine
  • Chlorophenylpyridamine
  • Chloroprophenpyridamine
  • Chlorphenamin
  • Chlorphenamine
  • Chlorprophenpyridamine
  • clorfenamina
  • dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
  • PYRIDINE, 2-(3-AMINOPROP-1-YL)-, γ-(4-CHLOROPHENYL)-N,N-DIMETHYL-
  • Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-
  • RS-Chlorpheniramine
  • γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
  • 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
  • Chloropiril
  • Chlorpheniraminum
  • EINECS 205-054-0
  • Chlorphenaminum
  • UNII-3U6IO1965U
  • chlorophenylpyridamine
  • clorfeniramina
  • gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
  • gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
  • 42882-96-2
  • 46970-45-0

Applications:

HPLC Separation of Drugs in Tylenol Cold and Cough Remedies
Components of Tylenol Cold and Cough Remedy are separated on Obelisc R mixed-mode column. Method can be used to determine compounds in various cough and cold compositions. Neutral (acetaminophen), basic (chlorpheniramine, dextromethorphan and pseudoephedrine) and acidic (maleic acid/Maleate) components are analyzed with perfect peak shape and retention control. Method can be used in production, QC/QA and biological studies for quantitation of various components in pharmaceutical formulations (Advil, Tylenol, Dimetapp, Robitussin, NyQuil, etc)

Condition
Column Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmFm
Flow Rate 1.0 ml/min
Detection UV, 270 nm
   

Description
Class of Compounds Drug, Analgetic, Acid, Hydrophilic, Ionizable, Neutral, Basic
Analyzing Compounds Maleate, Chlorpheniramine, Dextromethorphan, Pseudoephedrine,  Acetaminophen

Application Analytes:

Acetaminophen (Paracetamol)
Chlorpheniramine
Dextromethorphan
Maleate
Pseudoephedrine (PSE)