Chlortetracycline

CAS Number 57-62-5
Molecular Formula C22H23ClN2O8
Molecular Weight 478.881 g/mol
InChI Key CYDMQBQPVICBEU-XRNKAMNCSA-N
LogP -0.620
Synonyms
  • Chlortetracycline
  • (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
  • 57-62-5
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamin o)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pe ntahydroxy-6-methyl-1,11-dioxo-, (4S-(4.alpha.,4a. alpha.,5a.alpha.,6.beta.,12a.alpha.))-
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
  • [4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-Octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]-
  • 7-Chlorotetracycline
  • 7-Chlortetracycline
  • Acronize
  • Acronize PD
  • Aureocarmyl
  • Aureociclin
  • Aureocina
  • Aureomicina
  • Aureomycin
  • Aureomykoin
  • Aurofac
  • Biomycin
  • Biomycin a
  • Centraureo
  • Chlortetracyclin
  • Chrusomykine
  • Chrysomykine
  • clortetraciclina
  • Duomycin
  • Flamycin
  • Orospray
  • Tri-chlortetracycline
  • Uromycin
  • Aureomycin A-377
  • Biomitsin
  • Caswell No. 219B
  • EINECS 200-341-7
  • EPA Pesticide Chemical Code 006301
  • Chlortetracyclinum
  • UNII-WCK1KIQ23Q
  • Chlormax
  • 103651-17-8
  • 1236363-43-1
  • 856305-72-1
  • 96066-24-9
  • 96968-60-4
  • 98271-27-3

Applications:


Separation of Antibiotics in Mixed-mode chromatography

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).



Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Separation of Oxytetracycline and Chlortetracycline in Mixed-Mode

Oxytetracycline and chlortetracycline are polar compounds related to broad-spectrum of tetracycline group of antibiotics. Slight hydrophobicity and presence of the basic group in both compounds allow to employ mixed-mode reversed-phase cation-exchange mechanism for separation of these compounds. Method can be used for analysis of antibiotics and related impurities with LC/MS compatible conditions.



Application Analytes:

Chlortetracycline
Oxytetracycline