Codeine

CAS Number 76-57-3
Molecular Formula C18H21NO3
Molecular Weight 299.370 g/mol
InChI Key OROGSEYTTFOCAN-DNJOTXNNSA-N
LogP 0.761
Synonyms
  • Codeine
  • (5alpha,6alpha)-3-Methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-ol
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
  • 76-57-3
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)-
  • (-)-Codeine
  • codeina
  • Codicept
  • Coducept
  • l-Codeine
  • Methylmorphine
  • Morphinan-6α-ol, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methyl-
  • Morphine 3-methyl ether
  • Morphine monomethyl ether
  • O3-Methylmorphine
  • 7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
  • EINECS 200-969-1
  • Morphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methyl-
  • Morphine-3-methyl ester
  • UNII-UX6OWY2V7J
  • Codeinum
  • Codeine base
  • (1S,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,15-tetraen-14-ol
  • 7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol
  • Codein
  • Norcodeine, N-Methyl
  • Norcodine, N-Methyl
  • O(3)-methylmorphine
  • codeine anhydrous
  • morphine-3-methyl ether

Applications:


HPLC Separation of Codeine, Oxycodone, and Hydrocodone


Codeine, oxycodone, and hydrocodone are analgesics with hydrophobic and basic properties. All three compounds are used as strong pain killers and cough suppressant. These compounds are controlled substances according to DEA. We developed a simple method for separation of these narcotics on Primesep 100 and Primesep 200 mixed-mode columns. All three compounds are separated by reversed-phase and cation-exchange mechanism, based on the difference in hydrophobic and ionic properties. This HPLC approach can be used to develop and validate a generic method for analysis of analgesics and other drugs. Compounds are monitored by common detection techniques.



Application Analytes:

Codeine
Hydrocodone
Oxycodone

Analysis of Codeine-Based Drug Composition. Effect of Buffer Concentration and Buffer pH

Codeine and two parabens are separated by mixed-mode chromatography. Codeine is retained by reversed-phase and cation-exchange mechanisms and parabens are retained by reversed-phase mechanism. The retention time of codeine can be adjusted by changing the amount of acetonitrile, buffer concentration, and buffer pH. The mobile phase for this column and its separation are fully compatible with UV, ELSD, LC/MS and prep chromatography, various organic and inorganic acids, and corresponding buffers can be used.

Codeine is a hydrophobic basic drug which is used in many drug compositions as an analgetic, antitussive, anxiolytic, and sedative agent. Codeine is widely used as a moderate pain and cough reliever. It is usually part of complex composition and comes in the form of a tablet or syrup. Several preservatives are used in most of the drug composition and include parabens and benzoates. The mixture of codeine, methyl and propyl parabens was separated on Primesep C mixed-mode reversed-phase cation-exchange column. Codeine is retained by reversed-phase and cation-exchange mechanisms and parabens are retained by reversed-phase mechanism. No ion-pairing reagent is required since Primesep C mixed-mode stationary phase has an ion-pairing reagent attached to the surface.



Application Analytes:

Codeine
Methylparaben
Propylparaben

Analysis off Codeine-based Drug Composition. Effect of Buffer Concentration and Buffer PH



Application Analytes:

Codeine
Methylparaben
Propylparaben

Analysis of Codeine and Related Impurities in Drug Composition



Application Analytes:

Codeine
Methylparaben
Propylparaben