Dapsone

Dapsone structural formula

CAS Number 80-08-0
Molecular Formula C12H12N2O2S
Molecular Weight 248.301 g/mol
InChI Key MQJKPEGWNLWLTK-UHFFFAOYSA-N
LogP 0.97
Synonyms
  • Dapsone
  • 4,4'-Sulfonyldianiline
  • Benzenamine, 4,4'-sulfonylbis-
  • 80-08-0
  • 4,4'-Sulfonyldianiline
  • Benzenamine, 4,4'-sulfonylbis-
  • 1,1'-Sulfonylbis[4-aminobenzene]
  • 4,4'-Dapsone
  • 4,4'-Diaminodiphenyl sulfone
  • 4,4'-Diaminodiphenyl sulphone
  • 4,4'-DIAMINODIPHENYLSULFON
  • 4,4'-Sulfonylbisaniline
  • 4,4'-Sulfonylbisbenzamine
  • 4,4'-Sulfonyldiphenylamine
  • 4,4'-Sulphonyldianiline
  • 4-Aminophenyl sulfone
  • Aniline, 4,4'-sulfonyldi-
  • Aradur 976-1
  • Araldite HT 976
  • Avlosulfon
  • Avlosulphone
  • Bis(4-aminophenyl) sulfone
  • Bis(p-aminophenyl) sulfone
  • Croysulfone
  • Croysulphone
  • Di(4-aminophenyl)sulfone
  • Di(p-aminophenyl) sulfone
  • Diaphenylsulfon
  • Diaphenylsulfone
  • Diphenasone
  • DIPHENYL SULFONE, 4,4'-DIAMINO-
  • Diphone
  • Disulone
  • Dumitone
  • Hardener HT 976
  • Metabolite C
  • Novophone
  • NSC 6091
  • p,p'-Diaminodiphenyl sulfone
  • p,p'-Sulfonyldianiline
  • p-Aminophenyl sulfone
  • Seikacure S
  • Servidapson
  • Sulfona
  • Sulfona-Mae
  • Sulphadione
  • Sumicure S
  • Avlosulfone
  • Bis(p-aminophenyl)sulphone
  • Bis(4-aminophenyl)sulphone
  • BRN 0788055
  • Dapsona
  • Dapsonum
  • Diaminodiphenyl sulfone
  • Diamino-4,4'-diphenyl sulfone
  • p,p-Diaminodiphenyl sulphone
  • Diamino-4,4'-diphenyl sulphone
  • Di(4-aminophenyl) sulfone
  • Di(p-aminophenyl)sulphone
  • Di(4-aminophenyl)sulphone
  • Diaphenylsulphon
  • Diaphenylsulphone
  • N,N'-Diphenyl sulfondiamide
  • DSS (VAN)
  • Dubronax
  • EINECS 201-248-4
  • NCI-C01718
  • NSC-6091
  • NSC 6091D
  • Sulfadione
  • Sulfone, diphenyl, 4,4'-diamino-
  • Sulfone UCB
  • 1,1'-Sulfonylbis(4-aminobenzene)
  • p,p-Sulfonylbisbenzamine
  • p,p-Sulfonylbisbenzenamine
  • 1,1'-Sulphonylbis(4-aminobenzene)
  • 4,4'-Sulphonylbisbenzamine
  • 4,4'-Sulphonylbisbenzenamine
  • Sulphonyldianiline
  • p,p-Sulphonyldianiline
  • Tarimyl
  • 4,4'-Diaminodiphenyl suphone
  • 4,4-Diaminodifenylsulfon
  • Diaminodifenilsulfona
  • UNII-8W5C518302
  • 4,4'-Sulfonylbisbenzenamine
  • DADPS
  • DDS
  • Dapsone
  • p,p-sulphonylbisbenzamine
  • p,p-sulphonylbisbenzenamine
  • 1246638-15-2

Applications:

Separation of Antibiotics in Mixed-mode chromatography
  A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).  

Condition
Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description
Class of Compounds  Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine
 
Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tylosin
Analysis of Antibiotic Dapsone and Related Impurities in Mixed-Mode Chromatography
Separation type: Liquid Chromatography Mixed-mode



Dapsone is an antibiotic used to treat leprosy and acne. Obelisc R was used to analyze dapsone and its impurities. Obelisc R is a tri-modal reversed-phase, cation- and anion-exchange column. Method is compatible with LC/MS and prep chromatography.  

Condition
Column Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description
Class of Compounds  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Dapsone
 
Application Analytes:

Dapsone
HPLC Separation of Antibiotics
HPLC.cloud View on hplc.cloud Antibiotics are widely used for treatment and prevention of bacterial infections.  Various antibiotics, particularly those with a sulfanilamide structure, were separated in HPLC using mixed-mode columns with varying strengths of ion-pairing groups.  Primesep 200 has weak acidic ion-exchange pairing groups while Newcrom A has strong acidic ion-exchange groups.  In addition, methanol can be used in the mobile phase on Newcrom A column.  The antibiotics were resolved on both columns with a gradient mobile phase consisting of acetonitrile (ACN) or methanol (MeOH), water and sulfuric acid (H2SO4) buffer.  UV detection at 275nm.

Condition 1
Column Primesep 200, 4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN Gradient
Buffer H2SO4 - 0.5%
Flow Rate 1.0 ml/min
Detection UV 275 nm

Condition 2
Column Newcrom A, 3.2x100 mm, 5 µm, 100A
Mobile Phase MeOH Gradient
Buffer H2SO4 Gradient
Flow Rate  0.5 ml/min
Detection UV 275 nm
 

Description
Class of Compounds Drugs, Antibiotics
Analyzing Compounds Sulfanilamide, Sulfadiazine, Sulfaguanidine, Dapsone, Sulfaquinoxaline

Application Analytes:

Dapsone
Sulfadiazine
Sulfaguanidine
Sulfanilamide
Sulphaquinoxaline