Dapsone

CAS Number 80-08-0
Molecular Formula C12H12N2O2S
Molecular Weight 248.301 g/mol
InChI Key MQJKPEGWNLWLTK-UHFFFAOYSA-N
LogP 0.97
Synonyms
  • Dapsone
  • 4,4'-Sulfonyldianiline
  • Benzenamine, 4,4'-sulfonylbis-
  • 80-08-0
  • 4,4'-Sulfonyldianiline
  • Benzenamine, 4,4'-sulfonylbis-
  • 1,1'-Sulfonylbis[4-aminobenzene]
  • 4,4'-Dapsone
  • 4,4'-Diaminodiphenyl sulfone
  • 4,4'-Diaminodiphenyl sulphone
  • 4,4'-DIAMINODIPHENYLSULFON
  • 4,4'-Sulfonylbisaniline
  • 4,4'-Sulfonylbisbenzamine
  • 4,4'-Sulfonyldiphenylamine
  • 4,4'-Sulphonyldianiline
  • 4-Aminophenyl sulfone
  • Aniline, 4,4'-sulfonyldi-
  • Aradur 976-1
  • Araldite HT 976
  • Avlosulfon
  • Avlosulphone
  • Bis(4-aminophenyl) sulfone
  • Bis(p-aminophenyl) sulfone
  • Croysulfone
  • Croysulphone
  • Di(4-aminophenyl)sulfone
  • Di(p-aminophenyl) sulfone
  • Diaphenylsulfon
  • Diaphenylsulfone
  • Diphenasone
  • DIPHENYL SULFONE, 4,4'-DIAMINO-
  • Diphone
  • Disulone
  • Dumitone
  • Hardener HT 976
  • Metabolite C
  • Novophone
  • NSC 6091
  • p,p'-Diaminodiphenyl sulfone
  • p,p'-Sulfonyldianiline
  • p-Aminophenyl sulfone
  • Seikacure S
  • Servidapson
  • Sulfona
  • Sulfona-Mae
  • Sulphadione
  • Sumicure S
  • Avlosulfone
  • Bis(p-aminophenyl)sulphone
  • Bis(4-aminophenyl)sulphone
  • BRN 0788055
  • Dapsona
  • Dapsonum
  • Diaminodiphenyl sulfone
  • Diamino-4,4'-diphenyl sulfone
  • p,p-Diaminodiphenyl sulphone
  • Diamino-4,4'-diphenyl sulphone
  • Di(4-aminophenyl) sulfone
  • Di(p-aminophenyl)sulphone
  • Di(4-aminophenyl)sulphone
  • Diaphenylsulphon
  • Diaphenylsulphone
  • N,N'-Diphenyl sulfondiamide
  • DSS (VAN)
  • Dubronax
  • EINECS 201-248-4
  • NCI-C01718
  • NSC-6091
  • NSC 6091D
  • Sulfadione
  • Sulfone, diphenyl, 4,4'-diamino-
  • Sulfone UCB
  • 1,1'-Sulfonylbis(4-aminobenzene)
  • p,p-Sulfonylbisbenzamine
  • p,p-Sulfonylbisbenzenamine
  • 1,1'-Sulphonylbis(4-aminobenzene)
  • 4,4'-Sulphonylbisbenzamine
  • 4,4'-Sulphonylbisbenzenamine
  • Sulphonyldianiline
  • p,p-Sulphonyldianiline
  • Tarimyl
  • 4,4'-Diaminodiphenyl suphone
  • 4,4-Diaminodifenylsulfon
  • Diaminodifenilsulfona
  • UNII-8W5C518302
  • 4,4'-Sulfonylbisbenzenamine
  • DADPS
  • DDS
  • Dapsone
  • p,p-sulphonylbisbenzamine
  • p,p-sulphonylbisbenzenamine
  • 1246638-15-2

Applications:


Separation of Antibiotics in Mixed-mode chromatography
  A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).  

Condition

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds  Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine
 

Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Analysis of Antibiotic Dapsone and Related Impurities in Mixed-Mode Chromatography
Dapsone is an antibiotic used to treat leprosy and acne. Obelisc R was used to analyze dapsone and its impurities. Obelisc R is a tri-modal reversed-phase, cation- and anion-exchange column. Method is compatible with LC/MS and prep chromatography.  

Condition

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Dapsone
 

Application Analytes:

Dapsone