Diazinon

CAS Number 333-41-5
Molecular Formula C12H21N2O3PS
Molecular Weight 304.340 g/mol
InChI Key FHIVAFMUCKRCQO-UHFFFAOYSA-N
LogP 3.81
Synonyms
  • Diazinon
  • O,O-Diethyl O-[6-methyl-2-(propan-2-yl)pyrimidin-4-yl] phosphorothioate
  • Phosphorothioic acid, O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester
  • 333-41-5
  • 5-23-11-00187
  • Phosphorothioic acid, O,O-diethylO-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester
  • Antigal
  • Bassadinon
  • Basudin
  • Basudin 10G
  • Basudin S
  • Bazanon
  • Ciazinon
  • Compass
  • Dacutox
  • Dassitox
  • Delzinon
  • Diazinon 4E
  • Diazinon AG 500
  • Diazinon G
  • Diethyl 2-isopropyl-4-methyl-6-pyrimidinyl phosphorothionate
  • Diethyl 2-isopropyl-4-methyl-6-pyrimidyl thionophosphate
  • Dimpylat
  • Dimpylate
  • Disonex
  • Dizictol
  • Dizinil
  • Drawizon
  • Flytrol
  • Galesan
  • Garden Tox
  • Hi-Yield Imported Fire Ant Killer
  • KFM Blowfly Dressing
  • Kleen-Dok
  • Knox Out 2FM
  • Knox-out
  • Meodinon
  • Monothiophosphoric acid O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl) ester
  • NSC 8938
  • O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate
  • O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate
  • O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate
  • O,O-Diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate
  • O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)thiophosphoric acid
  • O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl) thiophosphate
  • O,O-Diethyl-O-(2-isopropyl-6-methylpyrimidin-4-yl)phosphorothioate
  • Oleodiazinon
  • Optimizer
  • Ortho Diazinon Ultra
  • PHOSPHOROTHIOATE O,O-DIETHYL O-[6-METHYL- 2-(ISOPROPYL)-4-PYRIMIDINYL]
  • Phosphorothioic acid O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester
  • Phosphorothioic acid, O,O-diethyl 2-isopropyl-6-methyl-4-pyrimidinyl ester
  • Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester
  • Phosphorothioic acid, O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester
  • Sarolex
  • Spectracide
  • Spectracide 25EC
  • Terminator
  • Basudin 10 G
  • Bazuden
  • BRN 0273790
  • Caswell No. 342
  • Diazajet
  • Diazide
  • Diazinone
  • Diazitol
  • O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl)phosphorothioate
  • Diethyl 4-(2-isopropyl-6-methylpyrimidinyl)phosphorothionate
  • O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate
  • O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl)phosphorothioate
  • O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate
  • O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl)phosphorothioate
  • Dizinon
  • EINECS 206-373-8
  • Ektoband
  • EPA Pesticide Chemical Code 057801
  • Geigy 24480
  • Isopropylmethylpyrimidyl diethyl thiophosphate
  • O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate
  • Kayazinon
  • Kayazol
  • Knox Out Yellow Jacket Contorl
  • NCI-C08673
  • Nedcidol
  • Neodinon
  • Nucidol
  • Phosphorothioate, O,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl)
  • Phosphorothioic acid, O,O-diethyl O-(isopropylmethylpyrimidinyl) ester
  • 4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate
  • Thiophosphoric acid 2-isopropyl-4-methyl-6-pyrimidyl diethyl ester
  • Cooper's Flystrike Powder
  • Dimpilato
  • Dimpylatum
  • O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat
  • O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiophosphat
  • O,O-Diethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat
  • O,O-Dietil-O-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato
  • Thiophosphate de O,O-diethyle et de O-2-isopropyl-4-methyl-6-pyrimidyle
  • UNII-YUS1M1Q929
  • O,O-Diethyl 2-isopropyl-4-methylpyrimidyl-6-thiophosphate
  • O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate
  • O,O-diethyl O-[6-methyl-2-(1-methylethyl)pyrimidin-4-yl] thiophosphate
  • Phosphorothioic acid, O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester
  • 27936-40-9
  • 30583-38-1
  • 65863-03-8

Applications:


HPLC Analysis of Diazinon
Diazinon is a nonsystemic organophosphate insecticide developed in the early 1950’s. It was heavily used as an all-purpose indoor/outdoor home pesticide, but was banned for home use in 2004. The thiophosphoric ester in diazinon can form toxic phosphine gases and phophorus oxides. The EURL included diazinon as a target pesticide for the EUPT-CF9. Obelisc R was used to retain diazinon and separate it from impurities. Obelisc R contains embedded ionic and hydrophobic groups which can assist in fine tuning separations. Method is LC/MS compatible and can be used as a general approach for analyzing diazinon and other organophosphate insecticides.

Condition 

Column Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN - 40%
Buffer AmFm pH 3.0- 20 mM
Flow Rate 1.0 ml/min
Detection UV, 250 nm
   

Description

Class of Compounds  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Diazinon
 

Application Analytes:

Diazinon

HPLC Separation of Diazinon on Obelisc and Primesep Mixed-Mode Columns
Diazinon is a nonsystemic organophosphate insecticide developed in the early 1950’s. It was heavily used as an all-purpose indoor/outdoor home pesticide, but was banned for home use in 2004. The thiophosphoric ester in diazinon can form toxic phosphine gases and phophorus oxides. The EURL (European Union Reference Laboratory), included diazinon as a target pesticide for the EUPT-CF9 a proficiency test for cereals and feedingstuff that require muli-residue methods. Primesep B2 and Obelisc R were used to retain carbofuran and separate it from impurities. Primesep B2 contains embedded basic ion-pairing groups and Obelisc R contains embedded ionic and hydrophobic groups which can assist in fine tuning separations. Method is LC/MS compatible and can be used as a general approach for analyzing diazinon, other organophosphate insecticides, and dozens of other pesticides.

Condition 1

Column Primesep B2, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10-70%, 15 min,  7 min hold
Buffer Gradient AmAc pH 4,5- 20-50 mM, 15 min,  7 min hold
Flow Rate 0.4 ml/min
Detection UV, 250 nm
 

Condition 2

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10-70%, 15 min,  7 min hold
Buffer Gradient AmAc pH 4,5- 20-50 mM, 15 min,  7 min hold
Flow Rate 0.4 ml/min
Detection UV, 250 nm
    <

Description

Class of Compounds  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Diazinon


Application Analytes:

Diazinon

HPLC Diazinon Analysis on Primesep 100 and Obelisc R columns
   

Diazinon is a thiophosphoric acid ester which was used to control cockroaches, fleas, and silverfish in residential buildings. Diazinon is considered to be toxic for vertebrates causing a number of observed symptoms such as convulsions, headaches, and vomiting. Diazinon was was outlawed for residential use in the U.S. in 2004, but can be used in agricultural industries. There is a lot of interest in analyzing diazinon: it was analyzed in an analysis of acidic compounds by the EURL (European Union Reference Library) using QuEChERS methodology. Primesep 100 and Obelisc R were used to separate diazinon with unique selectivity. Method is LC/MS compatible and can be replicated for dozens of pesticides.

 

Condition 1

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 25-70%, 15 min
Buffer Gradient AmAc pH 3.0- 30-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm
 

Condition 2

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10-70%, 15 min
Buffer Gradient AmAc pH 3.0- 20-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm
 

Condition 3

Column Primesep 100, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10-70%, 15 min
Buffer Gradient AmAc pH 3.0- 20-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds  Insecticide, Hydrophobic, Ionizable
Analyzing Compounds Diazinon
 

Application Analytes:

Diazinon

HPLC Method for Analysis of Pesticides: Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin

Condition 1

Column Primesep 100, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 35-85%, 6 min , 4 min hold
Buffer Gradient H2SO4 - 0.05- 0.15%, 6 min, 4 min hold
Flow Rate 0.6 ml/min
Detection UV, 230 nm
 

Condition 2

Column Primesep B2, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 35-85%, 6 min , 4 min hold
Buffer Gradient H2SO4 - 0.05- 0.15%, 6 min, 4 min hold
Flow Rate 0.6 ml/min
Detection UV, 230 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin
 

Application Analytes:

Alachlor
Aniline
Diazinon
Simazine
Thiabendazole
Thiamphenicol
Trifluralin