DMSO (Dimethyl sulfoxide)

CAS Number 67-68-5
Molecular Formula C2H6OS or (CH3)2SO
Molecular Weight 78.129 g/mol
InChI Key IAZDPXIOMUYVGZ-UHFFFAOYSA-N
LogP -0.6
Synonyms
  • dimethyl sulfoxide
  • DMSO
  • Methyl sulfoxide
  • 67-68-5
  • Methylsulfinylmethane
  • Dimethylsulfoxide
  • Dimethyl sulphoxide
  • Methane, sulfinylbis-
  • Demsodrox
  • Demasorb
  • Demavet
  • Dimexide
  • Domoso
  • Dromisol
  • Durasorb
  • Infiltrina
  • Somipront
  • Syntexan
  • Deltan
  • Demeso
  • Dolicur
  • Hyadur
  • sulfinylbismethane
  • Dimethyl sulfur oxide
  • Dermasorb
  • Dipirartril-tropico
  • Doligur
  • Kemsol
  • Topsym
  • Gamasol 90
  • Sclerosol
  • Sulfinylbis(methane)
  • Rimso-50
  • Dimethylsulfoxid
  • Dimethylsulfoxyde
  • Rimso 50
  • Dimethylsulphoxide
  • Caswell No. 381
  • SQ 9453
  • Dimetil sulfoxido
  • Sulfinylbis-methane
  • Dimethyli sulfoxidum
  • Topsym (rescinded)
  • Rimso-5
  • NSC-763
  • methanesulfinylmethane
  • Domoso (Veterinary)
  • CCRIS 943
  • (methylsulfinyl)methane
  • methylsulfoxide
  • (CH3)2SO
  • Dimexidum
  • DMS-90
  • sulfinyldimethane
  • NSC 763
  • Dimetilsolfossido [DCIT]
  • A 10846
  • Dimethyl sulpoxide
  • M 176
  • UNII-YOW8V9698H
  • HSDB 80
  • Methane, 1,1'-sulfinylbis-
  • EPA Pesticide Chemical Code 000177
  • DMS 70
  • DMS 90
  • DMS-70
  • Dimethylsulfoxyde [INN-French]
  • AI3-26477
  • Dimetil sulfoxido [INN-Spanish]
  • Dimethyli sulfoxidum [INN-Latin]
  • Methyl Sulfoxide: DMSO
  • EINECS 200-664-3
  • CHEMBL504
  • S(O)Me2
  • NSC763
  • YOW8V9698H
  • CHEBI:28262
  • IAZDPXIOMUYVGZ-UHFFFAOYSA-N
  • MFCD00002089
  • SQ-9453

Applications:


HPLC Separation of DMSO and Glycine by Mixed-Mode Chromatography
Dimethyl sulfoxide is important polar aprotic solvent, which is frequently used in pharmaceutical drug manufacturing, desolution, etc. DMSO is used as one of the solvents on protein chemistry due to universal ability to dissolve small molecules like amino acids. Amino acids and DMSO are very polar and have no retention on reversed-phase columns. In this HPLC application DMSO and glycine are separated on Primesep 100 mixed-mode column. DMSO is retained by weak reversed-phase mechanism and very low organic concentration is required in order to achieve any retention. Glycine, like any other underivatized amino acid, is retained by weak reversed-phase and moderate cation-exchange mechanism. Method uses acetonitrile/water/TFA gradient and UV detection.

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds DMSO, Glycine


Application Analytes:

Amino Acids
DMSO (Dimethyl sulfoxide)
Glycine

HPLC Separation of Mixture of DMF and DMSO
Dimethylformamide, DMF, is primarily used as an organic solvent and is miscible with water and most other organic liquids. Dimethyl sulfoxide (DMSO) is also a solvent. It can dissolve both polar and nonpolar compounds and is miscible with water and other organic liquids. Both compounds can be retained and separated using anhydrous (water-free) conditions using HPLC by SHARC 1 column, which uses hydrogen-bonding as a separation mechanism. The method uses a gradient of acetonitrile (ACN) and methanol (MeOH) mobile phase without the need for a buffer. UV detection used at 220nm.

Condition

Column Sharc 1, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 98-85 %, 10 min
Buffer No
Flow Rate 1.0 ml/min
Detection UV, 220 nm
 

Description

Class of Compounds Drug, Basic, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds DMF, DMSO
 

Application Analytes:

DMF (Dimethylformamide)
DMSO (Dimethyl sulfoxide)