Guaifenesin

Guaifenesin structural formula

CAS Number 93-14-1
Molecular Formula C10H14O4
Molecular Weight 198.219 g/mol
InChI Key HSRJKNPTNIJEKV-UHFFFAOYSA-N
LogP 1.39
Synonyms
  • Guaifenesin
  • 3-(2-Methoxyphenoxy)propane-1,2-diol
  • 1,2-Propanediol, 3-(2-methoxyphenoxy)-
  • 93-14-1
  • 4-06-00-05576
  • 1,2-Propanediol, 3-(2-methoxyphenoxy)-
  • 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane
  • 1,2-Propanediol, 3-(o-methoxyphenoxy)-
  • 3-(2-Methoxyphenoxy)-1,2-propanediol
  • 3-(o-Methoxyphenoxy)-1,2-propanediol
  • Actifed C
  • Aeronesin
  • Amonidren
  • Calmipan
  • Colrex Expectorant
  • Equicol
  • Glycerin guaiacolate
  • Glycerol guaiacolate
  • Glycerol α-(2-methoxyphenyl) ether
  • Glycerol α-(o-methoxyphenyl)ether
  • Glycerol α-guaiacyl ether
  • Glyceryl guaiacol ether
  • Glyceryl guaiacolate
  • Glyceryl guaiacolate ether
  • Glyceryl guaiacyl ether
  • Glycerylguaiacol
  • Glycodex
  • Glycotuss
  • Guaiacol glycerin ether
  • Guaiacol glycerol ether
  • Guaiacol glycerolether
  • GUAIACOL GLYCERYL ETHER
  • Guaiacuran
  • Guaiacurane
  • Guaiacyl glyceryl ether
  • Guaiamar
  • Guaianesin
  • guaifenesina
  • Guaifenesine
  • Guaiphenesin
  • Guaiphenesine
  • Guajacuran
  • Guayanesin
  • Hustosil
  • Methoxypropanediol
  • Methphenoxydiol
  • Miocurin
  • Mucinex
  • Muskurelax
  • Myocain
  • Myocaine
  • Myoscain
  • Neuroton
  • Neurotone
  • NSC 62112
  • o-Methoxyphenyl glyceryl ether
  • Organidin NR
  • PROPANE-1,2-DIOL, 3-(2-METHOXYPHENOXY)-
  • racemic-Guaifenesin
  • Relaxil G
  • Reorganin
  • Respenyl
  • Ritussin
  • Robitussin
  • Sirotol
  • Tenntus
  • Tenntuss
  • α-Glyceryl guaiacol ether
  • α-Glyceryl guaiacolate ether
  • Aether glycerinoguaiacolicus
  • Breonesin
  • BRN 2049375
  • Bronchol
  • Cortussin
  • Dorassin
  • EINECS 202-222-5
  • Flartussin
  • Gaiamar
  • Glycerin monoguaiacol ether
  • Glycerinmonoguaiacol ether
  • Glycero-guaiacol ether
  • Glycerol alpha-guaiacyl ether
  • Glycerol alpha-guiacyl ether
  • Glycerol alpha-(o-methoxyphenyl) ether
  • Glycerol alpha-(2-methoxyphenyl) ether
  • Glycerol alpha-(o-methoxyphenyl)ether
  • Glycerol alpha-monoguaiacol ether
  • Glycerol mono(2-methoxyphenyl) ether
  • Glycerol mono(2-methoxyphenyl)ether
  • Glycerol-alpha-monoguaiacol ether
  • Glyceryl guaiacol
  • alpha-Glyceryl guaiacol ether
  • alpha-Glyceryl guaiacolate ether
  • Glyceryl guaicolate
  • Glyceryl guiacolate
  • Gnaifenesin
  • Guaiacolglicerinetere
  • Guaiacolic acid, ester with glycerol
  • Guaia-rom
  • Guaicol glycerine ether
  • Guaicol glyceryl ether
  • Guaiphesin
  • Guajacol-alpha-glycerinether
  • Guajamar
  • Guiaphenesin
  • Hustodil
  • Metfenossidiolo
  • 3-o-Methoxyphenoxypropane 1:2-diol
  • Metossipropandiolo
  • Mintosyl
  • Miocaina
  • Miorelax
  • Mucostop
  • Myorelax
  • Myoscaine
  • 1,2,3-Propanetriol, ether with 2-methoxyphenol
  • Propanosedyl
  • Reduton
  • Relaxyl-G
  • (component of) Deconsal II
  • Glycerol-alpha-guajakolether
  • Guaifenesinum
  • Guajacol-glycerinaether
  • UNII-495W7451VQ
  • 12041-73-5
  • 128707-44-8
  • 1336-67-0

Applications:


HPLC Separation of Polar Drugs with MS-compatible Method
Acetaminophen is an over-the-counter pain and fever reducer, and a major component of cold and flue remedies. Phenylephrine is a decongestant. Guaifenesin is a mucolytic agent used to relieve respiratory difficulties. These three compounds of cough medication were separated by mixed-mode chromatography on a Primesep C HPLC column. Retention and order of elution for phenylephrine can be changed by buffer concentration and buffer pH. Method can be used for analysis of cough and cold composition during the production and in QC/QA environment. Method is compatible with LC/MS and can be used to analyze these components in biological fluids. This generic HPLC method is robust and reproducible.

Condition

Column Primesep C, 3x150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmAc
Flow Rate 0.5 ml/min
Detection UV, 270 nm
   

Description

Class of Compounds Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Pseudoephedrine, Guaifenesin


Application Analytes:

Acetaminophen (Paracetamol)
Guaifenesin
Phenylephrine

Effect of pH on Retention of Basic Compounds on Primesep C Columns
Method for separation of components of cough medication shows how retention for acetaminophen, phenylephrine and guaifenesin is controlled. Order of elution for compounds can be changed based on composition of the mobile phase. The method is compatible with UV, ELSD and LC/MS and can be used for quantitation of drugs in formulation. Primesep C mixed-mode HPLC column is ideal candidate for analysis of cough compositions. Basic compounds are well retained in mixed-mode chromatography without use of ion-pairing reagents. Several companies validated this approach. The method is reproducible and robust and can be used in both production environments and R&D. This HPLC method can be adopted as general approach for analysis of basic compounds in various mixtures.

Condition

Column Primesep C, 3x50 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmAc
Flow Rate 0.5 ml/min
Detection UV, 270 nm
   

Description

Class of Compounds Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Pseudoephedrine, Guaifenesin


Application Analytes:

Acetaminophen (Paracetamol)
Guaifenesin
Phenylephrine

HPLC Separation of Guaifenesin and Terbutaline





Application Analytes:

Guaifenesin
Terbutaline

USP Methods for the Analysis of Guaifenesin Using a Legacy L1 Column
  Application Notes: Guaifenesin is common, over the counter expectorant. Guaifenesin contain no less than 98 percent and not more than 102 percent of the labeled amount of guaifenesin calculated on a dried basis, according to the USP methods. the The USP HPLC method for the analysis of guaifenesin was developed on our Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Application Columns: Legacy L1 C18 HPLC column Application compounds: Guaifenesin, benzoic acid Mobile phase: MeOH/H2O/AcOH 40:60:1.5 Detection technique: UV Reference: USP 35- NF30  

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O/AcOH 40/60/1.5
Buffer NaH2PO4
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable, Acid
Analyzing Compounds Guaifenesin, Benzoic acid
 

Application Analytes:

Benzoic Acid
Guaifenesin