Hydrocodone

CAS Number 125-29-1
Molecular Formula C18H21NO3
Molecular Weight 299.370 g/mol
InChI Key LLPOLZWFYMWNKH-CMKMFDCUSA-N
LogP 1.42
Synonyms
  • Hydrocodone
  • (5alpha)-3-Methoxy-17-methyl-4,5-epoxymorphinan-6-one
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-
  • 125-29-1
  • 4-27-00-03580
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5α)-
  • (-)-Dihydrocodeinone
  • 6-Oxo-7,8-dihydrocodeine
  • Bekadid
  • Codeinone, dihydro-
  • Dicodid
  • Dihydrocodeinone
  • hidrocodona
  • Hydrocodon
  • Morphinan-6-one, 4,5α-epoxy-3-methoxy-17-methyl-
  • Multacodin
  • NSC 19044
  • BRN 0094193
  • Codinovo
  • EINECS 204-733-9
  • 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan
  • Hydrocodonum
  • UNII-6YKS4Y3WQ7
  • 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • Hydrocone
  • Hydroconum
  • Idrocodone
  • 1037-91-8
  • 9007-52-7
  • 50678-79-0
  • 1469752-80-4

Applications:


HPLC Separation of Codeine, Oxycodone, and Hydrocodone


Codeine, oxycodone, and hydrocodone are analgesics with hydrophobic and basic properties. All three compounds are used as strong pain killers and cough suppressant. These compounds are controlled substances according to DEA. We developed a simple method for separation of these narcotics on Primesep 100 and Primesep 200 mixed-mode columns. All three compounds are separated by reversed-phase and cation-exchange mechanism, based on the difference in hydrophobic and ionic properties. This HPLC approach can be used to develop and validate a generic method for analysis of analgesics and other drugs. Compounds are monitored by common detection techniques.



Application Analytes:

Codeine
Hydrocodone
Oxycodone

HPLC Method for Analysis of Vicodin (Acetaminophen & Hydrocodone)
78

Condition

Column Primesep 200, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 5-50%
Buffer Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm
   

Description

Class of Compounds Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Hydrocodone


Application Analytes:

Acetaminophen (Paracetamol)
Hydrocodone
Vicodin