Hydrocodone

Hydrocodone structural formula

CAS Number125-29-1
Molecular FormulaC18H21NO3
Molecular Weight299.370
InChI KeyLLPOLZWFYMWNKH-CMKMFDCUSA-N
LogP1.42
Synonyms
  • Hydrocodone
  • (5alpha)-3-Methoxy-17-methyl-4,5-epoxymorphinan-6-one
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-
  • 125-29-1
  • 4-27-00-03580
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5α)-
  • (-)-Dihydrocodeinone
  • 6-Oxo-7,8-dihydrocodeine
  • Bekadid
  • Codeinone, dihydro-
  • Dicodid
  • Dihydrocodeinone
  • hidrocodona
  • Hydrocodon
  • Morphinan-6-one, 4,5α-epoxy-3-methoxy-17-methyl-
  • Multacodin
  • NSC 19044
  • BRN 0094193
  • Codinovo
  • EINECS 204-733-9
  • 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan
  • Hydrocodonum
  • UNII-6YKS4Y3WQ7
  • 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • Hydrocone
  • Hydroconum
  • Idrocodone
  • 1037-91-8
  • 9007-52-7
  • 50678-79-0
  • 1469752-80-4

Applications:

HPLC Method for Analysis of Vicodin (Acetaminophen & Hydrocodone)

May 10, 2016

78

Condition

Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 5-50%
Buffer Gradient H3PO4 – 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

 

Description

Class of Compounds
Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Hydrocodone

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Acetaminophen (Paracetamol)
Hydrocodone
Vicodin

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Codeine, Oxycodone, and Hydrocodone

November 21, 2010


Codeine, oxycodone, and hydrocodone are analgesics with hydrophobic and basic properties. All three compounds are used as strong pain killers and cough suppressant. These compounds are controlled substances according to DEA. We developed a simple method for separation of these narcotics on Primesep 100 and Primesep 200 mixed-mode columns. All three compounds are separated by reversed-phase and cation-exchange mechanism, based on the difference in hydrophobic and ionic properties. This HPLC approach can be used to develop and validate a generic method for analysis of analgesics and other drugs. Compounds are monitored by common detection techniques.

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Codeine
Hydrocodone
Oxycodone

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.