Hydrocortisone

Hydrocortisone structural formula

CAS Number 50-23-7
Molecular Formula C21H30O5
Molecular Weight 362.467 g/mol
InChI Key JYGXADMDTFJGBT-VWUMJDOOSA-N
LogP 1.61
Synonyms
  • Hydrocortisone
  • (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
  • 50-23-7
  • Cortisol
  • CORT
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11β)-
  • (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11β,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11β,17,21-Trihydroxyprogesterone
  • 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
  • 11β-Hydroxycortisone
  • 17-Hydroxycorticosterone
  • 17α-Hydroxycorticosterone
  • 4-Pregnene-11β,17α,21-triol-3,20-dione
  • Acticort
  • Aeroseb HC
  • Ala-Cort
  • Anti-inflammatory hormone
  • CaldeCort Spray
  • Cetacort
  • Cobadex
  • Cortanal
  • Cort-Dome
  • Cortenema
  • Corticreme
  • Cortifan
  • Cortiment
  • Cortispray
  • Cortonema
  • Cortril
  • Dermacort
  • Dermocortal
  • Dermolate
  • Dihydrocostisone
  • Dioderm
  • Domolene-HC
  • Efcorbin
  • Efcortelan
  • Eldecort
  • Epiderm H
  • Esiderm H
  • Evacort
  • Ficortril
  • Genacort
  • Heb-Cort
  • Hidro-Colisona
  • hidrocortisona
  • Hycortol
  • Hycortole
  • Hydracort
  • Hydrasson
  • Hydro-Adreson
  • Hydrocort
  • Hydrocortal
  • Hydrocorticosterone
  • Hydrocortison
  • Hydrocortisyl
  • Hydrocortone
  • Hydroskin
  • Hytone lotion
  • Incortin-H
  • Kendall's compound F
  • Lacticare HC
  • Medicort
  • Mildison
  • NSC 10483
  • Nutracort
  • Otosone-F
  • Penecort
  • Permicort
  • Polcort H
  • Reichstein's substance M
  • Scheroson F
  • Synacort
  • Tarcortin
  • Texacort
  • Texacort lotion 25
  • Timocort
  • Traumaide
  • Zenoxone
  • EINECS 200-020-1
  • Eldercort
  • 11-beta-Hydrocortisone
  • 17alpha-Hydroxycorticosterone
  • Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
  • 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
  • Algicirtis
  • Dermaspray
  • Remederm HC
  • Colocort
  • Balneol-HC
  • Beta-HC
  • Flexicort
  • Glycort
  • Hydrocortisone in absorbase
  • Hydro-RX
  • Nogenic HC
  • Stie-Cort
  • Anucort
  • Anucort-HC
  • Proctozone HC
  • Rectasol-HC
  • Scalp-Cort
  • UNII-WI4X0X7BPJ
  • Proctosol-HC
  • (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
  • (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
  • 11-Hydrocortisone
  • 11-beta-Hydrocortisone
  • 11-beta-Hydroxycortisone
  • 11a-Hydroxycorticosterone
  • 11alpha-Hydroxycorticosterone
  • 11b,17,21-Trihydroxyprogesterone
  • 11b-Hydrocortisone
  • 11b-Hydroxycortisone
  • 11beta,17,21-Trihydroxyprogesterone
  • 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
  • 11beta-Hydroxycortisone
  • 11beta-hydrocortisone
  • 17a-Hydroxycorticosterone
  • 17alpha-Hydroxycorticosterone
  • 4-Pregnene-11alpha,21-triol 3,20-dione
  • 4-Pregnene-11b,17a,21-triol-3,20-dione
  • 4-pregnen-11beta,17alpha,21-triol-3,20-dione
  • Aeroseb-HC
  • Ala-Scalp
  • Alacort
  • Algicirtis
  • Alphaderm
  • Amberin
  • Anflam
  • Aquacort
  • Aquanil HC
  • Barseb HC
  • Basan-Corti
  • Chronocort
  • Clear aid
  • Cleiton
  • Compound F
  • Cor-Tar-Quin
  • Cort-Quin
  • Cortesal
  • Cortifoam
  • Cortisol alcohol
  • Cortisolonum
  • Cortisporin
  • Cortisporin Otico
  • Cortizol
  • Cortolotion
  • Cortonema
  • Cortoxide
  • Cremesone
  • Cremicort-H
  • Cutisol
  • Delacort
  • Derm-Aid
  • Dermil
  • Dome-cort
  • Drotic
  • Ef corlin
  • Efcortelin
  • Eldercort
  • Epicort
  • Fiocortril
  • Foille Insetti
  • Gyno-Cortisone
  • H-Cort
  • HC
  • Heb Cort
  • Hidalone
  • Hycort
  • Hycortol
  • Hydro-colisona
  • Hydrocortisone alcohol
  • Hydrocortisone base
  • Hydrocortisone free alcohol
  • Hydrocortisonum
  • Hydrocortistab
  • Hydroxycortisone
  • Hysone
  • Hytisone
  • Hytone
  • Idrocortisone
  • Incortin-hydrogen
  • Komed HC
  • Kyypakkaus
  • Lacticare-HC
  • Lactisona
  • Lubricort
  • Maintasone
  • Meusicort
  • Milliderm
  • Neo-Cort-Dome
  • Neosporin-H Ear
  • Nystaform-HC
  • Optef
  • Otalgine
  • Otic-Neo-Cort-Dome
  • Otobiotic
  • Otocort
  • Pediotic Suspension
  • Preparation H Hydrocortisone Cream
  • Prepcort
  • Prestwick_265
  • Prevex HC
  • Proctocort
  • Proctofoam
  • Protocort
  • Racet
  • Rectoid
  • Remederm HC
  • Sanatison
  • Scalpicin Capilar
  • Schericur
  • Sigmacort
  • Signef
  • Stiefcorcil
  • Systral Hydrocort
  • Topicort
  • Transderma H
  • Uniderm
  • Vioform-Hydrocortisone
  • VoSol HC
  • Vytone
  • 1050676-88-4
  • 8056-08-4
  • 80562-38-5
  • 8063-42-1

Applications:

HPLC Separation of Hydrocortisone and Hydrocortisone's Degradation Products
Cortisol (hydrocortisone) is a steroid hormone produced by the adrenal gland. Hydrocortisone is a hydrophobic neutral compound with some polar groups in its structure. Several Primesep mixed-mode columns were used for separation of hydrocortisone and its degradation products. Each column showed a different selectivity for separation, which attributed to different polar-embedded groups on Primesep 100 and Primesep D columns. Both columns can be used for degradation studies of various hydrophobic compounds.
Application Analytes:

HPLC Method for Analysis of Hydrocortisone
Hydrocortisone
Hydrocortisone
USP Methods for the Analysis of Hydrocortisone on a Legacy L1 Column
  Application Notes: Hydrocortisone is a naturally occurring hormone released during times of stress. Hydrocortisone has been synthesized and is used to treat diseases such as allergic reactions and skin conditions. According to the USP methods, hydrocortisone contains not less than 97 percent and not more than 102 percent of hydrocortisone calculated on the dried basis. The USP HPLC method for the separation of hydrocortisone was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Application Columns: Legacy L1 C18 HPLC column Application compounds: Hydrocortisone Mobile phase: MeCN/H2O 25:75 Detection technique: UV Reference: USP30: NF35

Condition
Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase NaH2PO4 pH 7.0/MeCN 88/12
Buffer NaH2PO4
Flow Rate 1.0 ml/min
Detection UV, 254 nm
 

Description
Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Nitrofurantoin
 
Application Analytes:

Hydrocortisone
HPLC Ananlysis of Hydrocortisone
  Hydrocortisone is the drug form of the steroid hormone cortisol. Cortisol is an important biological molecule which affects blood sugar, metabolism and the immune system. It was retained on the reverse-phase column Legacy L1. Comparisons of Legacy L1 and Phenomenex columns are available by request.

Condition
Column Legacy L1, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeCN - 40%
Buffer NaH2PO4 pH 2.5 - 10 mM
Flow Rate 1.0 ml/min
Detection UV, 210 nm

Description
Class of Compounds Hormone,   Hydrophobic, Ionizable
Analyzing Compounds Hydrocortisone
&
Application Analytes:

Hydrocortisone
HPLC Method for Analysis of Hydrocortisone
Chr_1055

Hydrocortisone, also known as 11β,17α,21-trihydroxypregn-4-ene-3,20-dione, is a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It is used to treat certain forms of arthritis as well various skin conditions (redness, swelling, and itching). Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Hydrocortisone. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
Application Analytes:

HPLC Ananlysis of Hydrocortisone
HPLC Method for Analysis of Hydrocortisone
HPLC Separation of Hydrocortisone and Hydrocortisone’s Degradation Products
Hydrocortisone