Josamycin

CAS Number 16846-24-5
Molecular Formula C42H69NO15
Molecular Weight 828.006 g/mol
InChI Key XJSFLOJWULLJQS-HTYUZQQASA-N
LogP 3.06
Synonyms
  • Josamycin
  • (2S,3R,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,6S,7R,9R,10R,11E,13E,16R)-4-(Acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl 3-methylbutanoate (non-preferred name)
  • 16846-24-5
  • Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
  • Antibiotic YL 704A3
  • Iosalide
  • Jomybel
  • Josacine
  • josamicina
  • Josamina
  • josamycine
  • Kitasamycin A3
  • Leucomycin A3
  • Turimycin A5
  • Vilprafen
  • Wilprafen
  • Antibiotic yl-704 A3
  • EINECS 240-871-6
  • Josamycinum
  • UNII-HV13HFS217

Applications:


Separation of Antibiotics in Mixed-mode chromatography

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).



Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Analysis of Antibiotic Josamycin and Related Impurities in Mixed-Mode Chromatography

 

Josamycin is a macrolide antibiotic effective against gram-positive bacteria. It is highly polar and does not retain well on reversed-phase columns. The Mixed-mode column Obelisc R was used to retain josamycin and its related impurities.  Primesep D was also used to analyze josamycin impurities because Primesep D does not retain high-molecular weight plasma components. This method is compatible with LC/MS, prep chromatography and can be used for analysis of josamycin in biofluids.



Application Analytes:

Josamycin

HPLC Separation of Antibiotics of Group in Mixed-Mode Chromatography

Primesep D was used to separate the antibiotics marbofloxacin, norfloxacin, josamycin, and flumequine. Primesep D is a reverse-phase column with embedded basic ion-pairing groups designed for analysis of plasma. This method is compatible with LC/MS and prep chromatography.



Application Analytes:

Flumequine
Josamycin
Marbofloxacin
Norfloxacin