| CAS Number | 443-48-1 |
|---|---|
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.157 g/mol |
| InChI Key | VAOCPAMSLUNLGC-UHFFFAOYSA-N |
| LogP | -0.0200 |
| Synonyms |
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Applications:
HPLC Retention Control of Antibiotics (Metronidazole and Norfloxacine) in Toothpaste
Commercially available toothpaste has been known to include antibiotics. To demonstrate the retention control on the mixed-mode column Primesep 100, toothpaste was spiked with the antibiotics metronidazole and norfloxacin. In a 13 minute method, retention of the antibiotics was controlled by adjustment in ratio of organic in the mobile phase. This method demonstrates the flexibility of using mixed-mode columns such as Primesep 100.
| Column | Primesep 100, 4.6x150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O |
| Buffer | H2SO4 |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 250 nm |
| Class of Compounds | Drug, Antibiotics, Hydrophilic, Ionizable |
| Analyzing Compounds | Metronidazole, Norfloxacine |
Application Analytes:
Metronidazole
Norfloxacin
HPLC Method for Analysis of Metronidazole
Application Analytes:
Metronidazole