Nicotinamide

CAS Number 98-92-0
Molecular Formula C6H6N2O
Molecular Weight 122.127 g/mol
InChI Key DFPAKSUCGFBDDF-UHFFFAOYSA-N
LogP -0.370
Synonyms
  • Niacinamide
  • Pyridine-3-carboxamide
  • 3-Pyridinecarboxamide
  • 98-92-0
  • Nicotinamide
  • 3-Pyridinecarboxamide
  • Nam
  • 3-(Aminocarbonyl)pyridine
  • 3-Amidopyridine
  • 3-Carbamoylpyridine
  • 3-Pyridinecarboxylic acid amide
  • Aminicotin
  • Benicot
  • Delonin Amide
  • Dipegyl
  • m-(Aminocarbonyl)pyridine
  • Niavit PP
  • Nicamina
  • Nicamindon
  • Nicasir
  • Nicobion
  • Nicofort
  • Nicosylamide
  • Nicotilamide
  • Nicotinamid
  • nicotinamida
  • Nicotine acid amide
  • Nicotinic acid amide
  • Nicotinic amide
  • Nicotylamide
  • Nicovit
  • Nicovitina
  • Nictoamide
  • Niocinamide
  • Niozymin
  • NSC 13128
  • NSC 27452
  • Papulex
  • Pelmine
  • Pelonin amide
  • PYRIDINE-3-CARBOXAMIDE
  • Vi-Nicotyl
  • Vitamin B
  • β-Pyridinecarboxamide
  • EINECS 202-713-4
  • Pyridine, 3-carbamoyl-
  • Nicotinsaureamid
  • UNII-25X51I8RD4
  • Acid amide
  • Amid kyseliny nikotinove
  • Amide PP
  • Amixicotyn
  • Amnicotin
  • Austrovit PP
  • Dipegyl
  • Dipigyl
  • Endobion
  • Factor pp
  • Hansamid
  • Inovitan PP
  • Mediatric
  • Nandervit-N
  • Niacevit
  • Niamide
  • Nicamide
  • Nicogen
  • Nicomidol
  • Nicosan 2
  • Nicota
  • Nicotamide
  • Nicotililamido
  • Nicotinamidum
  • Nicotine amide
  • Nicotinsaeureamid
  • Nicotinsaureamid
  • Nicotol
  • Nicotylamidum
  • Nicovel
  • Nicovitol
  • Nicozymin
  • Niko-tamin
  • Nikotinamid
  • Nikotinsaeureamid
  • PP-Faktor
  • Pelmin
  • Propamine A
  • Pyridine-3-carboxylic acid amide
  • Savacotyl
  • Vi-noctyl
  • Witamina PP
  • b-Pyridinecarboxamide
  • beta-pyridinecarboxamide
  • niacin
  • vitamin B3
  • 123574-63-0
  • 37321-14-5
  • 78731-47-2

Applications:


Separation of Nicotinamide and Related Substances

A complex mixture of nicotinamide and related impurities was separated on Obelisc R mixed-mode column. Nicotinamide, methylnicotinamide, nicotinamide adenine mononucleotide, nicotinamide adenine dinucleotide, and adenosine monophosphate were baseline resolved in a 15 minute long method. This mixed-mode approach can be used for analysis of other nucleotides. Obelisc R trimodal column separates this complex mixture based on reversed-phase, cation-exchange and anion-exchange mechanisms. Retention is controlled by amount of ACN, buffer concentration and buffer pH. Additional selectivity can be gained by exploring various buffers within the same pH



Application Analytes:

1-Methylnicotinamide
Adenosine Monophosphate
Nicotinamide
Nicotinamide Adenine Dinucleotide
Nicotinamide Adenine Mononucleotide

Analysis of Nicotinic Acid in Nicotinamide
Nicotinamide is the amide form of nicotinic acid. Nicotinic acid is in the vitamin B group and is converted to nicotinamide in vivo. Primesep 100 was used to separate nicotinamide and nicotinic acid. Concentrations of nicotinic acid as low as 0.1ppm could be used.Primesep 100 separates acids using ion-exclusion, retains basic compounds by cation-exchange, and neutral compounds by reverse-phase mechanism.

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 5/95%
Buffer Na2HPO4  pH 3.0- 10 mM
Flow Rate 1.0 ml/min
Detection UV, 230 nm
 

Description

Class of Compounds  Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Nicotinic Acid, Nicotinamide
 

Application Analytes:

Niacin
Nicotinamide
Nicotinic Acid