Nicotinamide

CAS Number	98-92-0
Molecular Formula	C6H6N2O
Molecular Weight	122.127 g/mol
InChI Key	DFPAKSUCGFBDDF-UHFFFAOYSA-N
LogP	-0.370
Synonyms	Niacinamide Pyridine-3-carboxamide 3-Pyridinecarboxamide 98-92-0 Nicotinamide 3-Pyridinecarboxamide Nam 3-(Aminocarbonyl)pyridine 3-Amidopyridine 3-Carbamoylpyridine 3-Pyridinecarboxylic acid amide Aminicotin Benicot Delonin Amide Dipegyl m-(Aminocarbonyl)pyridine Niavit PP Nicamina Nicamindon Nicasir Nicobion Nicofort Nicosylamide Nicotilamide Nicotinamid nicotinamida Nicotine acid amide Nicotinic acid amide Nicotinic amide Nicotylamide Nicovit Nicovitina Nictoamide Niocinamide Niozymin NSC 13128 NSC 27452 Papulex Pelmine Pelonin amide PYRIDINE-3-CARBOXAMIDE Vi-Nicotyl Vitamin B β-Pyridinecarboxamide EINECS 202-713-4 Pyridine, 3-carbamoyl- Nicotinsaureamid UNII-25X51I8RD4 Acid amide Amid kyseliny nikotinove Amide PP Amixicotyn Amnicotin Austrovit PP Dipegyl Dipigyl Endobion Factor pp Hansamid Inovitan PP Mediatric Nandervit-N Niacevit Niamide Nicamide Nicogen Nicomidol Nicosan 2 Nicota Nicotamide Nicotililamido Nicotinamidum Nicotine amide Nicotinsaeureamid Nicotinsaureamid Nicotol Nicotylamidum Nicovel Nicovitol Nicozymin Niko-tamin Nikotinamid Nikotinsaeureamid PP-Faktor Pelmin Propamine A Pyridine-3-carboxylic acid amide Savacotyl Vi-noctyl Witamina PP b-Pyridinecarboxamide beta-pyridinecarboxamide niacin vitamin B3 123574-63-0 37321-14-5 78731-47-2

Applications:

Separation of Nicotinamide and Related Substances

A complex mixture of nicotinamide and related impurities was separated on Obelisc R mixed-mode column. Nicotinamide, methylnicotinamide, nicotinamide adenine mononucleotide, nicotinamide adenine dinucleotide, and adenosine monophosphate were baseline resolved in a 15 minute long method. This mixed-mode approach can be used for analysis of other nucleotides. Obelisc R trimodal column separates this complex mixture based on reversed-phase, cation-exchange and anion-exchange mechanisms. Retention is controlled by amount of ACN, buffer concentration and buffer pH. Additional selectivity can be gained by exploring various buffers within the same pH

1-Methylnicotinamide
Adenosine Monophosphate
Nicotinamide
Nicotinamide Adenine Dinucleotide
Nicotinamide Adenine Mononucleotide

Analysis of Nicotinic Acid in Nicotinamide

Nicotinamide is the amide form of nicotinic acid. Nicotinic acid is in the vitamin B group and is converted to nicotinamide in vivo. Primesep 100 was used to separate nicotinamide and nicotinic acid. Concentrations of nicotinic acid as low as 0.1ppm could be used.Primesep 100 separates acids using ion-exclusion, retains basic compounds by cation-exchange, and neutral compounds by reverse-phase mechanism.

Niacin
Nicotinamide
Nicotinic Acid