Nitrofurantoin

CAS Number	67-20-9
Molecular Formula	C8H6N4O5
Molecular Weight	238.159 g/mol
InChI Key	NXFQHRVNIOXGAQ-UHFFFAOYSA-N
LogP	-0.470
Synonyms	Nitrofurantoin 1-{[(5-Nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]- 67-20-9 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]- 1-(5-Nitro-2-furfurylidenamino)hydantoin 1-(5-Nitro-2-furfurylideneamino)hydantoin 1-[(5-Nitrofurfurylidene)amino]hydantoin 5-Nitrofurantoin Berkfurin Chemiofuran Cyantin Furachel Furadantin Furadantine MC Furadantoin Furadoin Furadoine Furadonin Furadonine Furadontin Furalan Furantoin Furantoina Furatoin Furobactina Furophen T-Caps Fur-ren Hydantoin, 1-[(5-nitrofurfurylidene)amino]- Macrobid Macrodantin N-(5-Nitro-2-furfurylidene)-1-aminohydantoin N-(5-Nitro-2-furfurylidine)-1-aminohydantoin N-(5-Nitrofurfurylidene)-1-aminohydantoin Nifurantin nitrofurantoina Nitrofurantoine Novofuran NSC 2107 NSC 44150 Orafuran Parfuran Trantoin Urantoin Urizept Urofurin Urolong Uro-Tablinen Welfurin Zoofurin Benkfuran Berkfuran Dantafur EINECS 200-646-5 Fua Med Furadantine Furadoninum Furagin Furaloid NCI-C55196 Nierofu Nitrofuradantin 1-((5-Nitrofurfurylidene)amino)hydantoin Nitrofur-C Furedan Alfuran Ceduran Cistofuran Furabid Furadantin Retard Furadantina MC Furadantine-MC Furophen T Gerofuran Macrodantina Macrofuran Macrofurin Nifuretten Phenurin PiyEloseptyl Ro-Antoin Siraliden Uerineks Urofuran Urolisa Uro-Selz Nitrofurantoin, macrocrystalline N-(5-Nitro-2-furfurylideno)-1-aminohydantoina Nitrofurantoinum UNII-927AH8112L

Applications:

HPLC Separation of Common Antibiotics in Fish Farming

Fish antibiotics are used in fish farming to treat bacterial diseases of fish. It is common practice in the fish industry, particularly in developing countries, to use large amounts of antibiotics to prevent infection. The antibiotics used are often non-biodegradable and remain in the environment for long periods of time, contaminating soil and ground waters. In farming antibiotics are mixed with food and residual amount of drugs ends up in fish products and poultry, this lead to consumption of antibiotics and metabolites by humans. Five common antibiotics are separated on Primesep C column using LC/MS compatible conditions. Method can be used for quantitative determination of nitrofurantoin, nitrofurazone, furazolidone, furaltadone, chloramphenicol and nitrofurazone in fish products and environment.

5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin
Nitrofurazone

HPLC Separation of Antibiotics in Fish Production

Five antibiotics are separated on Primesep C mixed-mode cation-exchange column using UV, ESLD and LC/MS compatible conditions. Similar compounds can be separated based on reverse phase and cation-exchange mechanisms. Current method can be used in quantitative determination of antibiotics in various food products.

5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin

USP Methods for Nitrofurantoin for the Legacy L1 Column

Application Notes: Nitrofurantoin is an antibiotic used to treat urinary tract infections and E. coli. The USP HPLC method for the separation of nitrofuranton was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS. Application Columns: Legacy L1 C18 HPLC column Application compounds: Nitrofurantoin Mobile phase: NaH2PO4 pH 7.0/MeCN 88/12 Detection technique: UV Reference: USP35: NF30

Nitrofurantoin

Application USP Methods for Nitrofurantoin for the Legacy L1

Nitrofurantoin