Nitrofurantoin

Nitrofurantoin structural formula

CAS Number67-20-9
Molecular FormulaC8H6N4O5
Molecular Weight238.159
InChI KeyNXFQHRVNIOXGAQ-UHFFFAOYSA-N
LogP-0.470
Synonyms
  • Nitrofurantoin
  • 1-{[(5-Nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione
  • 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]-
  • 67-20-9
  • 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]-
  • 1-(5-Nitro-2-furfurylidenamino)hydantoin
  • 1-(5-Nitro-2-furfurylideneamino)hydantoin
  • 1-[(5-Nitrofurfurylidene)amino]hydantoin
  • 5-Nitrofurantoin
  • Berkfurin
  • Chemiofuran
  • Cyantin
  • Furachel
  • Furadantin
  • Furadantine MC
  • Furadantoin
  • Furadoin
  • Furadoine
  • Furadonin
  • Furadonine
  • Furadontin
  • Furalan
  • Furantoin
  • Furantoina
  • Furatoin
  • Furobactina
  • Furophen T-Caps
  • Fur-ren
  • Hydantoin, 1-[(5-nitrofurfurylidene)amino]-
  • Macrobid
  • Macrodantin
  • N-(5-Nitro-2-furfurylidene)-1-aminohydantoin
  • N-(5-Nitro-2-furfurylidine)-1-aminohydantoin
  • N-(5-Nitrofurfurylidene)-1-aminohydantoin
  • Nifurantin
  • nitrofurantoina
  • Nitrofurantoine
  • Novofuran
  • NSC 2107
  • NSC 44150
  • Orafuran
  • Parfuran
  • Trantoin
  • Urantoin
  • Urizept
  • Urofurin
  • Urolong
  • Uro-Tablinen
  • Welfurin
  • Zoofurin
  • Benkfuran
  • Berkfuran
  • Dantafur
  • EINECS 200-646-5
  • Fua Med
  • Furadantine
  • Furadoninum
  • Furagin
  • Furaloid
  • NCI-C55196
  • Nierofu
  • Nitrofuradantin
  • 1-((5-Nitrofurfurylidene)amino)hydantoin
  • Nitrofur-C
  • Furedan
  • Alfuran
  • Ceduran
  • Cistofuran
  • Furabid
  • Furadantin Retard
  • Furadantina MC
  • Furadantine-MC
  • Furophen T
  • Gerofuran
  • Macrodantina
  • Macrofuran
  • Macrofurin
  • Nifuretten
  • Phenurin
  • PiyEloseptyl
  • Ro-Antoin
  • Siraliden
  • Uerineks
  • Urofuran
  • Urolisa
  • Uro-Selz
  • Nitrofurantoin, macrocrystalline
  • N-(5-Nitro-2-furfurylideno)-1-aminohydantoina
  • Nitrofurantoinum
  • UNII-927AH8112L

Applications:

Application USP Methods for Nitrofurantoin for the Legacy L1

February 20, 2019

Application USP Methods for Nitrofurantoin for the Legacy L1

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.

Select options
Application Analytes:
Nitrofurantoin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

USP Methods for Nitrofurantoin for the Legacy L1 Column

June 21, 2012

USP Methods for Nitrofurantoin for the Legacy L1 Column

 

Application Notes: Nitrofurantoin is an antibiotic used to treat urinary tract infections and E. coli. The USP HPLC method for the separation of nitrofuranton was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.

Application Columns: Legacy L1 C18 HPLC column

Application compounds: Nitrofurantoin

Mobile phase: NaH2PO4 pH 7.0/MeCN 88/12

Detection technique: UV

Reference: USP35: NF30

Condition
Column Legacy L1, 4.6×150 mm, 5 µm, 100A
Mobile Phase : NaH2PO4 pH 7.0/MeCN 88/12
Buffer NaH2PO4
Flow Rate 1.0 ml/min
Detection UV, 254 nm

 

Description
Class of Compounds
 Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Nitrofurantoin

 

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.

Select options
Application Analytes:
Nitrofurantoin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Antibiotics in Fish Production

August 22, 2008

Five antibiotics are separated on Primesep C mixed-mode cation-exchange column using UV, ESLD and LC/MS compatible conditions. Similar compounds can be separated based on reverse phase and cation-exchange mechanisms. Current method can be used in quantitative determination of antibiotics in various food products.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Common Antibiotics in Fish Farming

December 6, 2007

Fish antibiotics are used in fish farming to treat bacterial diseases of fish. It is common practice in the fish industry, particularly in developing countries, to use large amounts of antibiotics to prevent infection. The antibiotics used are often non-biodegradable and remain in the environment for long periods of time, contaminating soil and ground waters. In farming antibiotics are mixed with food and residual amount of drugs ends up in fish products and poultry, this lead to consumption of antibiotics and metabolites by humans. Five common antibiotics are separated on Primesep C column using LC/MS compatible conditions. Method can be used for quantitative determination of nitrofurantoin, nitrofurazone, furazolidone, furaltadone, chloramphenicol and nitrofurazone in fish products and environment.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin
Nitrofurazone
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.