Norfloxacin

CAS Number 70458-96-7
Molecular Formula C16H18FN3O3
Molecular Weight 319.336 g/mol
InChI Key OGJPXUAPXNRGGI-UHFFFAOYSA-N
LogP -1.03
Synonyms
  • Norfloxacin
  • 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
  • 70458-96-7
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • Amicrobin
  • Baccidal
  • Barazan
  • Chibroxin
  • Chibroxine
  • Chibroxol
  • Esclebin
  • Floxacin
  • Floxacin 400
  • Fulgram
  • Gonorcin
  • Lexinor
  • N-Demethylpefloxacin
  • N-Desmethylpefloxacin
  • Neofloxacin
  • Neofloxin
  • Nolicin
  • Noracin
  • Noraxin
  • Norflox 400
  • Norfloxacine
  • norfloxacino
  • Norfloxin
  • Norocin
  • Noroxin
  • Noroxine
  • Norphloxacine
  • Norxacin
  • Sebercim
  • Spectrama
  • Uroflox
  • Uroxacin
  • Zoroxin
  • BRN 0567897
  • 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • EINECS 274-614-4
  • Norfloxacinum
  • UNII-N0F8P22L1P
  • 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • NFLX

Applications:


Separation of Antibiotics in Mixed-mode chromatography

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).



Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Analysis of Antibiotic Norfloxacin and Related Impurities in Mixed-Mode Chromatography

 

 

 

 

The antibiotic norfloxacin is a first generation fluoroquinolone. It is effective against both gram positive and gram negative bacteria. Analysis was done on Obelisc R and Primesep D.



Application Analytes:

Norfloxacin

HPLC Separation of Antibiotics of Group in Mixed-Mode Chromatography

Primesep D was used to separate the antibiotics marbofloxacin, norfloxacin, josamycin, and flumequine. Primesep D is a reverse-phase column with embedded basic ion-pairing groups designed for analysis of plasma. This method is compatible with LC/MS and prep chromatography.



Application Analytes:

Flumequine
Josamycin
Marbofloxacin
Norfloxacin

HPLC Retention Control of Antibiotics in Toothpaste

 

Commercially available toothpaste has been known to include antibiotics. To demonstrate the retention control on the mixed-mode column Primesep 100, toothpaste was spiked with the antibiotics metronidazole and norfloxacin. In a 13 minute method, retention of the antibiotics was controlled by adjustment in ratio of organic in the mobile phase. This method demonstrates the flexibility of using mixed-mode columns such as Primesep 100.



Application Analytes:

Metronidazole
Norfloxacin