Oxycodone structural formula

CAS Number 76-42-6
Molecular Formula C18H21NO4
Molecular Weight 315.369 g/mol
LogP 0.922
  • Oxycodone
  • (5alpha)-14-Hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-one
  • Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-
  • 76-42-6
  • Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5α)-
  • (-)-Oxycodone
  • 14-Hydroxydihydrocodeinone
  • 3-O-(Methyl)oxymorphone
  • 6-Oxo-14-hydroxy-7,8-dihydrocodeine
  • 7,8-Dihydro-14-hydroxycodeinone
  • Codeinone, 7,8-dihydro-14-hydroxy-
  • Dihydro-14-hydroxycodeinone
  • Dihydrohydroxycodeinone
  • Dihydrone
  • Morphinan-6-one, 4,5α-epoxy-14-hydroxy-3-methoxy-17-methyl-
  • NSC 19043
  • oxicodona
  • Oxycodeinone
  • Oxycodon
  • Oxymorphone 3-methyl ether
  • Pavinal
  • BRN 0043446
  • Codeinone, dihydrohydroxy-
  • Codeinone, dihydro-14-hydroxy-
  • Diphydrone
  • EINECS 200-960-2
  • Endine
  • Eucodalum
  • (-)-14-Hydroxydihydrocodeinone
  • Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-
  • Oxanest
  • Pancodone retard
  • Percobarb
  • Ossicodone
  • Oxycodonum
  • Supendol
  • UNII-CD35PMG570
  • Oxyfast
  • Oxycodone Concentrate
  • PF-00345439
  • 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • Dihydrohydroxycodeinone
  • Dihydroxycodeinone


HPLC Separation of Codeine, Oxycodone, and Hydrocodone

Codeine, oxycodone, and hydrocodone are analgesics with hydrophobic and basic properties. All three compounds are used as strong pain killers and cough suppressant. These compounds are controlled substances according to DEA. We developed a simple method for separation of these narcotics on Primesep 100 and Primesep 200 mixed-mode columns. All three compounds are separated by reversed-phase and cation-exchange mechanism, based on the difference in hydrophobic and ionic properties. This HPLC approach can be used to develop and validate a generic method for analysis of analgesics and other drugs. Compounds are monitored by common detection techniques.

Application Analytes:


HPLC Method for Analysis of Acetaminophen and Oxycodone
11 Acetaminophen is a p-aminophenol derivative with analgesic and antipyretic activities. It has weak anti-inflammatory properties, may cause liver, blood cell, and kidney damage. It is a nonprescription medication for mild-to-moderate pain and fever. Oxycodone is semi-synthetic opioid type drug that is used to help relieve moderate to severe pain. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Acetaminophen and Oxycodone. The method is UV compatible and can be used as a general approach for analyzing similar compounds.


Column Primesep 200, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 5-50%
Buffer Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm


Class of Compounds Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Hydrocodone

Application Analytes:

Acetaminophen (Paracetamol)