Picolinic Acid

Picolinic Acid structural formula

CAS Number 98-98-6
Molecular Formula C6H5NO2
Molecular Weight 123.112 g/mol
LogP 0.72
  • Picolinic acid
  • Pyridine-2-carboxylic acid
  • 2-Pyridinecarboxylic acid
  • 98-98-6
  • 5-22-02-00003
  • 2-Pyridinecarboxylic acid
  • 2-Carboxypyridine
  • 2-Pyridylcarboxylic acid
  • Acide pyridine-2-carboxylique
  • acido piridina-2-carboxilico
  • NSC 171
  • o-Pyridinecarboxylic acid
  • Pyridin-2-carbonsaure
  • pyridine-2-carboxylic acid
  • α-Pyridinecarboxylic acid
  • BRN 0109595
  • EINECS 202-719-7
  • NSC 21209
  • 2-Methoxy-5-aminopyridine
  • 2-Picolinic acid
  • 4,5-Dehydropipecolic acid
  • 5-Amino-2-Pyridinecarboxylic acid
  • 5-Amino-2-fluoropyridine
  • 5-Amino-2-methoxypyridine
  • 5-Aminopicolinic acid
  • 5-Aminopyridine-2-carboxylic acid
  • 6-Methoxy-pyridin-3-ylamine
  • Acide picolique
  • L-Baikiain
  • PLA
  • Phenyl-(2-pyridyl)acetonitrile
  • Picolinate
  • Pyridine-carboxylique-2
  • Pyridinecarboxylic acid-(2)
  • a-Pyridinecarboxylic acid
  • alpha-picolinic acid
  • alpha-pyridinecarboxylic acid


HPLC Separation of Pyridinecarboxylic Acids
Pyridinecarboxylic acids exist as three isomers with different position of carboxylic acid relative to nitrogen in pyridine. Three isomers of pyridinecarboxylic acid (picolinic or 2-pyridinecarvoxylic acid, niacin or 3-pyridinecarboxylic acid, isonicotinic or 4-pyridinecarboxylic acid), along with pyridinedicarboxylic acid, are separated on a Primesep 100 column. Pyridinecarboxylic acids have a similar empirical formula, and are very similar in terms of hydrophobicity and ionic properties. Small differences in these properties are enough to achieve good separation on cation-exchange mixed-mode HPLC column like Primesep 100. Retention time for all compounds is controlled by the amount of acetonitrile and amount of ions in the mobile phase. Ions in the mobile phase can be created by organic and inorganic acids and corresponding salt buffers. Various detection techniques can be used for monitoring pyridinecarboxylic acids. Other ionizable isomers can be successfully separated on mixed-mode columns.

Application Analytes:

Isonicotinic Acid
Nicotinic Acid/Niacin (3-pyridinecarboxylic acid)
Organic Acids
Picolinic Acid
Pyridinedicarboxylic Acid