Promethazine

Promethazine structural formula

CAS Number 60-87-7
Molecular Formula C17H20N2S
Molecular Weight 284.421 g/mol
InChI Key PWWVAXIEGOYWEE-UHFFFAOYSA-N
LogP 4.81
Synonyms
  • Promethazine
  • N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
  • 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-
  • 60-87-7
  • 4-27-00-01253
  • 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-
  • (.+-.)-Promethazine
  • (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
  • 10-[2-(Dimethylamino)propyl]phenothiazine
  • Diphergan
  • N,N,α-Trimethyl-10H-phenothiazine-10-ethanamine
  • NSC 30321
  • Phenothiazine, 10-[2-(dimethylamino)propyl]-
  • Proazamine
  • Prometazin
  • prometazina
  • Promethazin
  • Protazine
  • Prothazin
  • Vallergine
  • BRN 0088554
  • N-Dimethylamino-2-methylethyl thiodiphenylamine
  • N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
  • 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
  • 10-(2-(Dimethylamino)propyl)phenothiazine
  • Diprazine
  • EINECS 200-489-2
  • Fenetazine
  • Histargan
  • Lilly 01516
  • NCI-C60673
  • Phargan
  • Phenargan
  • Phensedyl
  • Promazinamide
  • Promezathine
  • Pyrethiazine
  • Tanidil
  • Thiergan
  • Antiallersin
  • Camergan
  • Metaryl
  • Pelpica
  • Phenerzine
  • Phenoject-50
  • Pilothia
  • Pipolphene
  • Promacot
  • Promergan
  • Promesan
  • Prometh
  • PromethazineHcl
  • Dimethylamino-isopropyl-phenthiazin
  • Promethazinum
  • UNII-FF28EJQ494
  • 10-(2-Dimethylaminopropyl)phenothiazine
  • N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine
  • N-(2'-dimethylamino-2'-methyl)ethylphenothiazine
  • 73745-50-3

Applications:

HPLC Analysis of Promethazine
  Promethazine is a drug used as an antihistamine, a sedative, and used to reduce motion sickness, and prescribed for insomnia. The reverse-phase column Legacy L1 was used to retain promethazine. comparisons between Legacy L1 and Phenomenex columns are available upon request.

Condition
Column Legacy L1, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeCN - 35%
Buffer NaH2PO4 pH 2.5 - 20 mM
Flow Rate 1.0 ml/min
Detection UV, 254 nm

Description
Class of Compounds  Drug,  Hydrophobic, Ionizable
Analyzing Compounds Promethazine
&
Application Analytes:

Promethazine