Propylparaben

CAS Number	94-13-3
Molecular Formula	C10H12O3
Molecular Weight	180.204 g/mol
InChI Key	QELSKZZBTMNZEB-UHFFFAOYSA-N
LogP	3.04
Synonyms	Propylparaben Propyl 4-hydroxybenzoate Benzoic acid, 4-hydroxy-, propyl ester 94-13-3 Propyl-4-hydroxybenzoate 4-10-00-00374 Benzoic acid, 4-hydroxy-, propyl ester 4-hidroxibenzoato de propilo 4-Hydroxybenzoate de propyle 4-HYDROXYBENZOESAEURE-PROPYLESTER 4-Hydroxybenzoic acid propyl ester 4-HYDROXYBENZOIC ACID PROPYLESTER Aseptoform P BENZOATE, 4-HYDROXY-, PROPYL Benzoic acid, p-hydroxy-, propyl ester Bonomold OP Chemocide PK Mekkings P Nipagin P Nipasol Nipasol M Nipasol P Nipazol n-Propyl 4-hydroxybenzoate n-Propylparaben NSC 23515 NSC 8511 Paraben Paraben P Paseptol p-Hydroxybenzoic acid propyl ester p-Hydroxybenzoic acid, propyl ester p-Hydroxybenzoic propyl ester Preserval P Propagin propyl 4-hydroxybenzoate Propyl Butex Propyl Chemosept PROPYL PARABEN PROPYL P-HYDROXYBENZOATE propyl p-oxybenzoate Propyl-4-hydroxybenzoat Propylparasept Pulvis conservans Solbrol P Tegosept P BRN 1103245 Caswell No. 714 EINECS 202-307-7 EPA Pesticide Chemical Code 061203 FEMA No. 2951 FEMA Number 2951 p-Oxybenzoesaurepropylester Propylester kyseliny p-hydroxybenzoove UNII-Z8IX2SC1OH Bayer D 206 4-Hydroxybenzoic acid, propyl ester Betacide p Betacine p Chemacide PK Chemoside PK Lexgard p N-Propyl-p-hydroxybenzoate P-Hydroxybenzoic acid N-propyl ester P-Hydroxybenzoic acid, propyl ester Propyl aseptoform Propyl chemsept Propyl parahydroxybenzoate Propyl parasept Propyl-4-hydroxybenzoate Propyl-paraben Propylparaben, USAN Protaben p n-Propyl p-hydroxybenzoate p-Hydroxypropyl benzoate p-Oxybenzoesaeurepropylester 58339-85-8 59593-07-6

Applications:

HPLC Separation of Parabens and Benzoic Acid

Parabens possess antibacterial and antifungal properties and are therefore widely used in pharmaceutical and cosmetic industries as preservatives in products. Parabens and benzoic acid can be baseline separated in a short time frame using Primesep B2 reverse-phase HPLC column with a simple mobile phase of water, acetonitrile (ACN, MeCN) and phosphoric acid of 0.1% as buffer. UV detection at 210nm.

Benzoic Acid
Methylparaben
Parabens
Propylparaben

HPLC Separation of Polar and Hydrophobic Drugs on Obelisc R and N

DOPA (3,4-dihydroxy-L-phenylalanine)
Dopamine
Propylparaben

HPLC Separation of Methyl Paraben, Benzonitrile, Propyl Paraben, and Toluene on Mixed-Mode and Reverse Phase Columns

Parabens are common preservatives in pharmaceutical and cosmetic industries. They are esters of p-hydroxybenzoic acid. Method for separation of methyl paraben, propyl paraben, benzonitrile and toluene was developed on a Obelisc R column. All four compounds are neutral and are retained by reverse-phase mechanism. In case of reversed-phase stationary phase, no effect of pH is observed. Retention time for all four compounds changes on an Obelisc R column when pH is changed. pH of the mobile phase affects ionization state of stationary phase. Obelisc R column has C12 carbon chain and carboxylic acid with pKa of 4. At lower pH (pH 2, TFA), carboxylic acid of stationary phase is not ionized and thus adds hydrophobicity to stationary phase. Obelisc R column can be used for analysis of basic, acidic and neutral compounds with suitable detection techniques - UV, ELSD, CAD, LC/MS.

Benzonitrile
Methylparaben
Propylparaben
Toluene

Analysis of Codeine-Based Drug Composition. Effect of Buffer Concentration and Buffer pH

Codeine and two parabens are separated by mixed-mode chromatography. Codeine is retained by reversed-phase and cation-exchange mechanisms and parabens are retained by reversed-phase mechanism. The retention time of codeine can be adjusted by changing the amount of acetonitrile, buffer concentration, and buffer pH. The mobile phase for this column and its separation are fully compatible with UV, ELSD, LC/MS and prep chromatography, various organic and inorganic acids, and corresponding buffers can be used.

Codeine is a hydrophobic basic drug which is used in many drug compositions as an analgetic, antitussive, anxiolytic, and sedative agent. Codeine is widely used as a moderate pain and cough reliever. It is usually part of complex composition and comes in the form of a tablet or syrup. Several preservatives are used in most of the drug composition and include parabens and benzoates. The mixture of codeine, methyl and propyl parabens was separated on Primesep C mixed-mode reversed-phase cation-exchange column. Codeine is retained by reversed-phase and cation-exchange mechanisms and parabens are retained by reversed-phase mechanism. No ion-pairing reagent is required since Primesep C mixed-mode stationary phase has an ion-pairing reagent attached to the surface.

Codeine
Methylparaben
Propylparaben

Analysis off Codeine-based Drug Composition. Effect of Buffer Concentration and Buffer PH

Codeine
Methylparaben
Propylparaben

Analysis of Codeine and Related Impurities in Drug Composition

Codeine
Methylparaben
Propylparaben

Analysis of Dextromethorphan-Based Composition

Bromide
Dextromethorphan
Methylparaben
Propylparaben

Analysis of Dextromethorphan-Based Drug composition. Effect on buffer pH

Dextromethorphan is one of the common cough suppressants used in many drug composition. It is in tablets and syrups as an antitussive drug. Composition often has preservatives like parabens. Dextromethorphan is a hydrophobic, basic drug which is used as a bromide salt in drug compositions. Dextromethorphan and two parabens (methyl paraben and propyl paraben) were separated on Primesep C reversed-phase cation-exchange column. Several impurities were observed and are well separated from the main components of the drug composition. Method can be used for various formulations in QC and production environment.

Bromide
Dextromethorphan
Methylparaben
Propylparaben

HPLC Analysis of Propylparaben

Propyl 4-hydroxybenzoate or propylparaben is a very useful compound in cosmetics and often used as a preservative in lotions and creams. The reverse-phase column Legacy L1 was used to retain propyl 4-hydroxybenzoate. Comparisons to Phenomenex columns are available upon request.

Propylparaben

HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column

Carbocisteine
Methylparaben
Methylparaben sodium
Propylparaben
Propylparaben sodium