Sulfamethoxazole

CAS Number 723-46-6
Molecular Formula C10H11N3O3S
Molecular Weight 253.276 g/mol
InChI Key JLKIGFTWXXRPMT-UHFFFAOYSA-N
LogP 0.9
Synonyms
  • Sulfamethoxazole
  • Sulphamethoxazole
  • Sulfisomezole
  • Gantanol
  • Sulfamethoxazol
  • Metoxal
  • Sulfamethylisoxazole
  • Simsinomin
  • Radonil
  • Sinomin
  • Sulphamethoxazol
  • Sulpha-methoxizole
  • Sulfamethalazole
  • Azo-gantanol
  • 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
  • Sulphamethylisoxazole
  • Urobak
  • Sulfamethoxizole
  • 3-Sulfanilamido-5-methylisoxazole
  • Gantanol-DS
  • 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  • Bactrimel
  • Gamazole
  • Azo gantanol
  • Sulfametoxazol
  • Sulphisomezole
  • Solfametossazolo
  • Sulfamethoxazolum
  • 5-Methyl-3-sulfanilamidoisoxazole
  • Ro 4-2130
  • MS 53
  • 3-Sulphanilamido-5-methylisoxazole
  • Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-
  • 5-Methyl-3-sulphanil-amidoisoxazole
  • 3-(p-Aminophenylsulfonamido)-5-methylisoxazole
  • 5-Methyl-3-sulfanylamidoisoxazole
  • N'-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N1-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N'-(5-Methylisoxazol-3-yl)sulphanilamide

Applications:


Separation of Antibiotics in Mixed-mode chromatography
  A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).  

Condition

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds  Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine
 

Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tylosin

HPLC Method For Analysis Of Sulfamethoxazole and Trimethoprim on Primesep 100 Column
Separation type: Liquid Chromatography Mixed-mode

HPLC.cloud View on hplc.cloud

High Performance Liquid Chromatography (HPLC) Method for Analysis of Sulfamethoxazole and Trimethoprim

Condition

Column Primesep 100, Newcrom R1 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 40/60%
Buffer H2SO4 - 0.4%
Flow Rate 1.0 ml/min
Detection UV, 200 nm,
 

Description

Class of Compounds Drug
Analyzing Compounds Sulfamethoxazole, Trimethoprim
 

Application Analytes:

Sulfamethoxazole
Trimethoprim