Sulfamethoxazole

CAS Number 723-46-6
Molecular Formula C10H11N3O3S
Molecular Weight 253.276 g/mol
InChI Key JLKIGFTWXXRPMT-UHFFFAOYSA-N
LogP 0.9
Synonyms
  • Sulfamethoxazole
  • Sulphamethoxazole
  • Sulfisomezole
  • Gantanol
  • Sulfamethoxazol
  • Metoxal
  • Sulfamethylisoxazole
  • Simsinomin
  • Radonil
  • Sinomin
  • Sulphamethoxazol
  • Sulpha-methoxizole
  • Sulfamethalazole
  • Azo-gantanol
  • 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
  • Sulphamethylisoxazole
  • Urobak
  • Sulfamethoxizole
  • 3-Sulfanilamido-5-methylisoxazole
  • Gantanol-DS
  • 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  • Bactrimel
  • Gamazole
  • Azo gantanol
  • Sulfametoxazol
  • Sulphisomezole
  • Solfametossazolo
  • Sulfamethoxazolum
  • 5-Methyl-3-sulfanilamidoisoxazole
  • Ro 4-2130
  • MS 53
  • 3-Sulphanilamido-5-methylisoxazole
  • Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-
  • 5-Methyl-3-sulphanil-amidoisoxazole
  • 3-(p-Aminophenylsulfonamido)-5-methylisoxazole
  • 5-Methyl-3-sulfanylamidoisoxazole
  • N'-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N1-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N'-(5-Methylisoxazol-3-yl)sulphanilamide

Applications:


Separation of Antibiotics in Mixed-mode chromatography
  A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).  

Condition

Column Obelisc R, 2.1x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid - 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds  Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine
 

Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin