Tartaric Acid

CAS Number 87-69-4
Molecular Formula C4H6O6
Molecular Weight 150.086 g/mol
LogP -1.47
  • L-Tartaric acid
  • (2R,3R)-2,3-Dihydroxybutanedioic acid
  • Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-
  • 87-69-4
  • L-(+)-Tartaric acid
  • Butanedioic acid, 2,3-dihydroxy- (2R,3R)-
  • (+)-(2R,3R)-Tartaric acid
  • (+)-(R,R)-Tartaric acid
  • (+)-L-Tartaric acid
  • (+)-tartaric acid
  • (+)-Weinsaure
  • (2R,3R)-(+)-Tartaric acid
  • (2R,3R)-2,3-Dihydroxysuccinic acid
  • (2R,3R)-Tartaric acid
  • (R,R)-(+)-Tartaric acid
  • (R,R)-Tartaric acid
  • 1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • 2,3-Dihydroxybutanedioic acid
  • 2R,3R-Tartaric acid
  • Acide (+)-tartrique
  • acido (+)-tartarico
  • Butanedioic acid, 2,3-dihydroxy- [R-(R*,R*)]-
  • Butanedioic acid, 2,3-dihydroxy-, [R-(R*,R*)]-
  • Butanedioic acid, 2,3-dihydroxy-[R-(R*,R*)]-
  • Dextrotartaric acid
  • Dihydroxysuccinic acid
  • d-α,β-Dihydroxysuccinic acid
  • Natural tartaric acid
  • NSC 62778
  • Succinic acid, 2,3-dihydroxy
  • Tartaric Acid AR (1LB/BT)
  • Tartaric acid, L-(+)-
  • Threaric acid
  • d-alpha,beta-Dihydroxysuccinic acid
  • EINECS 201-766-0
  • Kyselina 2,3-dihydroxybutandiova
  • Kyselina vinna
  • UNII-W4888I119H
  • (+)-Weinsaeure
  • (+)-tartarate
  • (1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • (2R,3R)-2,3-Dihydroxybernsteinsaeure
  • (2R,3R)-2,3-dihydroxybutanedioate
  • (2R,3R)-2,3-tartaric acid
  • (2R,3R)-Tartarate
  • (R,R)-tartarate
  • (R,R)-tartaric acid
  • 2,3-Dihydroxy-succinate
  • 2,3-Dihydroxy-succinic acid
  • 2,3-Dihydroxybutanedioate
  • 2,3-Dihydroxysuccinic acid
  • D-Tartaric acid
  • D-a,b-Dihydroxysuccinic acid
  • L(+)-Tartaric acid
  • L-Tartarate
  • L-threaric acid
  • Rechtsweinsaeure
  • TAR
  • TLA
  • Tartarate
  • Weinsteinsaeure
  • 1039646-76-8
  • 1336-18-1
  • 8014-54-8
  • 8059-77-6
  • 1334703-49-9


HILIC Separation of Carboxylic Acids

Hydrophilic acids are separated on Obelisc N mixed-mode HILIC column. Seven carboxylic acids are separated based on their polarity and pKa values. Changes in ionization states of acids and stationary phase can be used to control elution order of organic and inorganic acids.

Application Analytes:

Fumaric Acid
Hydroxybenzoic Acid
Malic Acid
Mandelic Acid
Methylmalonic Acid
Organic Acids
Succinic Acid
Tartaric Acid

HPLC Analysis of Basic Drugs and Acidic Counter-Ions by Mixed-Mode Chromatography
The majority of drugs in the pharmaceutical industry are administered in salt form. The presence of two counter-ions very often necessitates the use of two methods. The nature of these counterparts in drugs can be an inorganic cation and organic acid, inorganic anion and organic base, and organic cation and organic anion. Furthermore, the properties of the molecules will result in a differing stoichiometry. The task of simultaneous quantitation of counter-ions can be achieved by using mixed-mode columns. The general approach for analysis is based on properties of corresponding counter-ions. Hydrophobic basic drugs, like dextromethorphan, verapamil, trimipramine, and corresponding acidic counter-ions (chloride, chlorate, bromide, bromate, perchlorate, maleate, fumarate,tartrate, succinate, phosphate, citrate, benzosulfonate, toleuensulfonate) can be separated and quantitated in the same run on reversed-phase anion-exchange column. Basic hydrophobic drugs are retained by the reversed-phase mechanism, and counter-ions are retained by the reversed-phase and anion-exchange mechanism. Some polar counter-ions are retained only by the anion-exchange mechanism. Retention time and selectivity of HPLC separation of drugs and counter-ions can be achieved by changing the amount of acetonitrile and the amount of ions in the mobile phase. The detection technique depends on the properties of the counter-ions. In case of low or no UV activity, ELSD can be employed if the counter-ion forms a non-volatile salt with the mobile phase additive (ammonium formate). This HPLC method can be used for simultaneous quantitation of other basic drugs and counter-ions. The presence of two mechanisms of retention allows control over retention times of drug and counter-ion independently, and even allows a change of order of elution when necessary.

Application Analytes:

Benzenesulfonic Acid
Citric Acid
Fumaric Acid
Maleic Acid
Organic Acids
Phosphoric Acid
Succinic Acid
Tartaric Acid
p-Toluenesulfonic Acid (PTSA)

HPLC Separation of Small Organic Acids on Newcrom B Column
HPLC.cloud View on hplc.cloud  


Column Newcrom B, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 5/95%
Buffer AmAc pH 5.0, Formic Acid
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase


Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Glycolic acid, Succinic Acid, Methylmalonic acid, Malic Acid, Maleic Acid, Citric Acid, Tartaric Acid, Fumaric Acid, Malonic Acid

Application Analytes:

Citric Acid
Fumaric Acid
Glycolic acid sodium salt
Maleic Acid
Malic Acid
Malonic Acid
Methylmalonic Acid
Succinic Acid
Tartaric Acid
dl-Tartaric acid