Theophylline

Theophylline structural formula

CAS Number 58-55-9
Molecular Formula C7H8N4O2
Molecular Weight 180.168 g/mol
InChI Key ZFXYFBGIUFBOJW-UHFFFAOYSA-N
LogP -0.0200
Synonyms
  • Theophylline
  • 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
  • 58-55-9
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
  • 1,3-Dimethylxanthine
  • 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-
  • 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
  • Accurbron
  • Aerobin
  • Aerolate
  • Afonilm
  • Armophylline
  • Bilordyl
  • Brochoretard
  • Bronkodyl
  • Cetraphylline
  • Chronophyllin
  • Constant T
  • Controfilina 200
  • Diffumal
  • Duraphyl
  • Duraphyllin
  • Egifilin
  • Elixophyllin
  • Elixophylline
  • Etheophyl
  • Euphylong
  • Insanovin
  • Lanophyllin
  • Liquophylline
  • NSC 2066
  • Optiphyllin
  • Parkophyllin
  • phylobid
  • Physpan
  • Pro-Vent
  • Pseudotheophylline
  • PulmiDur
  • Pulmo-Timelets
  • Quibron T
  • Quibron T/SR
  • Respbid
  • Respicur
  • Slo-Bid
  • Slo-Phyllin
  • Solosin
  • Somophyllin CRT
  • Somophyllin T
  • Spophyllin retard
  • Sustaire
  • Talotren
  • Telbans
  • Telbans Dry Syrup
  • Telb-DS
  • teofilina
  • Teonova
  • Theobid
  • Theobid Duracap
  • Theochron
  • Theoclear
  • Theodel
  • Theodrip
  • Theo-DS
  • Theo-Dur
  • Theodur Dry Syrup
  • Theofol
  • Theograd
  • Theolair
  • Theona P
  • Theo-Nite
  • Theopek
  • Theophyl
  • Theophyllin
  • THEOPHYLLINE ANHYDROUS
  • Theoplus
  • Theo-Sav
  • Theostat
  • Theotard
  • Theovent
  • Unicontin CR
  • Unilong
  • Uniphyl
  • Uniphyllin
  • Xanthium
  • EINECS 200-385-7
  • Purine-2,6(1H,3H)-dione, 1,3-dimethyl-
  • Theophylline, anhydrous
  • Xanthine, 1,3-dimethyl-
  • Theodur
  • UNII-0I55128JYK
  • 1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 1,3-dimethyl-7H-purine-2,6-dione
  • Acet-theocin
  • Aerolate III
  • Aerolate SR
  • Aminophylline
  • Aquaphyllin
  • Asbron
  • Asmax
  • Austyn
  • Bronkodyl SR
  • Choledyl SA
  • Constant-T
  • Diphyllin
  • Doraphyllin
  • Dyspne-Inhal
  • Elixex
  • Elixicon
  • Elixomin
  • Elixophyllin SR
  • Euphylline
  • Euphylong
  • Labid
  • Liquorice
  • Maphylline
  • Medaphyllin
  • Nuelin
  • Quibron-T
  • Quibron-T/Sr
  • Slo-Phyllin
  • Somophyllin-Crt
  • Somophyllin-DF
  • Somophyllin-T
  • Synophylate
  • Synophylate-L.A. Cenules
  • T-Phyl
  • Tefamin
  • Teofyllamin
  • Teolair
  • Theacitin
  • Theal tabl.
  • Theal tablets
  • Theo-Dur-Sprinkle
  • Theobid Jr.
  • Theocin
  • Theoclair-SR
  • Theoclear 80
  • Theoclear L.A.-130
  • Theoclear LA
  • Theoclear-200
  • Theoclear-80
  • Theocontin
  • Theolair-Sr
  • Theolix
  • Theolixir
  • Theophyl-225
  • Theophyl-Sr
  • Theophyline
  • Theophylline-Sr
  • Theostat 80
  • Uni-Dur
  • Unifyl
  • Uniphyl
  • Xantivent
  • 111079-49-3
  • 46157-00-0
  • 56645-32-0
  • 75448-53-2

Applications:


Effect of Acid on Separation of Xanthines
Primesep B separates xanthines such as theobromine, dimethylxanthine, theophylline by a combination of reversed-phase and ion-exchange mechanisms. The anion-exchange properties of the column allow retention of hydrophilic xanthines, and the reversed-phase properties retain hydrophobic compounds. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN) and either trifluoroacetic acid (TFA), perchloric acid (HClO4), or sulfuric acid (H2SO4) and UV detection.

Condition

Column Primesep B
Mobile Phase MeCN/H2O
Buffer TFA , HClO4, H2SO4
Flow Rate 1.0 ml/min
Detection
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Hormone
Analyzing Compounds Theobromine, 1,7 - Dimethylxanthine, Theophyline
 

Application Analytes:

Theophylline
Theophylline monohydrate

Separation of Theophylline monohydrate on Newcrom R1 HPLC column

Theophylline monohydrate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Theophylline monohydrate on Newcrom R1 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Theophylline
Theophylline monohydrate

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