Xanthine

CAS Number 69-89-6
Molecular Formula C5H4N4O2
Molecular Weight 152.114 g/mol
InChI Key LRFVTYWOQMYALW-UHFFFAOYSA-N
LogP -0.730
Synonyms
  • Xanthine
  • 3,7-Dihydro-1H-purine-2,6-dione
  • 1H-Purine-2,6-dione, 3,7-dihydro-
  • 69-89-6
  • 1H-Purine-2,6-dione, 3,7-dihydro-
  • 1H,3H,7H-Xanthine
  • 1H,3H,9H-Xanthine
  • 1H-Purine-2,6-diol
  • 1H-Purine-2,6-dione, 3,9-dihydro-
  • 2,6-Dioxo-1,2,3,6-tetrahydropurine
  • 2,6-Dioxopurine
  • 3,7-Dihydro-1H-purine-2,6-dione;2,6-(1H,3H)-purinedione, Xanthine
  • 3,9-Dihydro-1H-purine-2,6-dione
  • 3,9-Dihydropurine-2,6-dione
  • 9H-Purine-2,6(1H,3H)-dione
  • Isoxanthine
  • NSC 14664
  • Pseudoxanthine
  • Purin-2(3H),6(1H)-dion
  • purina-2(3H),6(1H)-diona
  • Purine-2(3H),6(1H)-dione
  • Purine-2,6(1H,3H)-dione
  • Xanthic oxide
  • Xanthin
  • EINECS 200-718-6
  • Purine-2,6-(1H,3H)-dione
  • EPA Pesticide Chemical Code 116900
  • UNII-1AVZ07U9S7
  • 2,6-dihydroxypurine
  • 9H-purine-2,6-(1H,3H)-dione
  • Xan
  • 9H-xanthine
  • 2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 2,6(1,3)-Purinedion
  • 3,7-Dihydro-1H-purine-2,6-dione
  • 3,7-Dihydropurine-2,6-dione
  • 9H-Purine-2,6(1H,3H)-dione
  • 9H-Purine-2,6-diol
  • Dioxopurine
  • Purine-2,6-diol
  • 7H-xanthine
  • 16819-86-6
  • 28522-58-9
  • 33669-67-9
  • 42911-15-9
  • 51953-26-5
  • 6050-36-8
  • 6053-41-4

Applications:


HILIC Retention of Polar Compounds on Primesep S


Three neutral polar compounds (urea, thiourea, and xanthine) are separated on a Primesep S HILIC cation-exchange column with LC/MS compatible mobile phase. The retention time is controlled by the amount of acetonitrile in the mobile phase.



Application Analytes:

Thiourea
Urea
Xanthine

HPLC Separation of Caffeine, 3- Methylxanthine, 1- Methylxanthine, Xanthine
    Application Notes: Xanthines are polar neutral compounds which are hard to retain and separate by traditional reversed-phase chromatography. However a hydrogen bonding method makes separation possible due to an observable correlation between the number of hydrogens available for interaction and retention time. Molecules with no hydrogens available for interactions retain less, and compound with multiple hydrogen donors retain the most. Retention time can be controlled by changing ratio of ACN:MeOH. Other protic and aprotic solvents can be used to control retention time and selectivity of separation. Application Columns: SHARC 1, 3.2x100 mm, 5 um, 100A, To learn more about SHARC 1 columns click here. To order this column click here. To see more chromatographic separations check our web site. Application Compounds:  Caffeine, 3-methylxanthine, 1-methylxanthine, and xanthine

Application Analytes:

1-Methylxanthine
3-Methylxanthine
Caffeine
Xanthine