Oxytetracycline

CAS Number 79-57-2
Molecular Formula C22H24N2O9
Molecular Weight 460.439 g/mol
InChI Key IWVCMVBTMGNXQD-PXOLEDIWSA-N
LogP -0.900
Synonyms
  • Oxytetracycline
  • (4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6S,12aS)-
  • 79-57-2
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S-(4.alpha.,4a.alpha.,5.alpha.,5a.alpha.,6.beta.,12a.alpha.))-
  • 4-14-00-02633
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6S,12aS)-
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,6β,12aα)]-
  • 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • 5-Hydroxytetracycline
  • Abbocin
  • Adamycin
  • Antibiotic TM 25
  • Berkmycen
  • Biostat
  • Biostat PA
  • Dabicycline
  • Fanterrin
  • Geomycin
  • Geotilin
  • Imperacin
  • Lenocycline
  • Liquamycin
  • Liquamycin LA 200
  • Macocyn
  • Mycoshield TMQTHC 20
  • NSC 9169
  • Oksisyklin
  • Oxatets
  • oxitetraciclina
  • Oxitetracyclin
  • Oxycline
  • Oxyject LA
  • Oxy-Kesso-Tetra
  • Oxymycin
  • Oxymykoin
  • Oxyteracycline
  • Oxyterracin
  • Oxyterracine
  • Oxyterracyne
  • Oxytetracyclin
  • Oxytetracycline amphoteric
  • Oxytetral
  • Proteroxyna
  • Riomitsin
  • Ryomycin
  • Solkaciclina
  • Stecsolin
  • Stevacin
  • Stevasin
  • Tarocyn
  • Tarosin
  • Teravit
  • Terrafungine
  • Terralon LA
  • Terramycin
  • Terramycin 343
  • Terramycin Q 50
  • Unimycin
  • Ursocyclin
  • Ursocycline
  • Vendarcin
  • BRN 2714587
  • EINECS 201-212-8
  • NCI-C56473
  • NSC-9169
  • Oxitetracyclinum
  • Terramitsin
  • Terramycin Q50
  • Terramycin im
  • Tetracycline, 5-hydroxy-
  • Ossitetraciclina
  • Oxytetracyclinum
  • UNII-SLF0D9077S
  • Terramicina Oftalmica
  • Oxytetracycline (anhydrous)
  • oxytetracycline zwitterion
  • 102287-29-6
  • 103351-03-7
  • 105145-10-6
  • 106216-57-3
  • 1135442-00-0
  • 1256964-22-3
  • 1405-95-4
  • 21645-09-0
  • 52214-46-7
  • 856305-69-6
  • 96310-42-8

Applications:


Separation of Antibiotics in Mixed-mode chromatography

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).



Application Analytes:

Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Separation of Oxytetracycline and Chlortetracycline in Mixed-Mode

Oxytetracycline and chlortetracycline are polar compounds related to broad-spectrum of tetracycline group of antibiotics. Slight hydrophobicity and presence of the basic group in both compounds allow to employ mixed-mode reversed-phase cation-exchange mechanism for separation of these compounds. Method can be used for analysis of antibiotics and related impurities with LC/MS compatible conditions.



Application Analytes:

Chlortetracycline
Oxytetracycline