Dextromethorphan hydrobromide

CAS Number 125-69-9
Molecular Formula C18H26BrNO
Molecular Weight 352.317 g/mol
LogP 3.75
  • Dextromethorphan hydrobromide
  • (9alpha,13alpha,14alpha)-3-Methoxy-17-methylmorphinan--hydrogen bromide (1/1)
  • Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-, hydrobromide (1:1)
  • 125-69-9
  • Morphinan, 3-methoxy-17-methyl-, hydrobromide (1:1),(9alpha,13alpha,14alpha)-
  • d-3-Methoxy-N-methylmorphinan hydrobromide
  • Morphinan, 3-methoxy-17-methyl-, hydrobromide (9alpha,13alpha,14alpha)-
  • 9alpha,13alpha,14alpha -Morphinan, 3-methoxy-17-methyl-, hydrobromide
  • Alpha-dextromethorphan
  • Antussan
  • Codiphan
  • Coldex-D
  • Colfed
  • d-Methorphan hydrobromide
  • Delsym
  • Demorphan
  • Demorphine
  • Detosiv Slow Release
  • Dextromethorphan bromide
  • Dextroramin P
  • Dormetan
  • Dormethan
  • Medicon
  • Methorate hydrobromide
  • Metrorat
  • Nocuf
  • Ro 1-5470
  • Romilar
  • Tosse Sedativo
  • Tusilan
  • Tussade
  • Dextrometorphan hydrobromide
  • EINECS 204-750-1
  • 9-alpha,13-alpha,14-alpha-Morphinan, 3-methoxy-17-methyl-, hydrobromide
  • Ro 1-5470/5
  • Romilar hydrobromide
  • Allfen-DM
  • UNII-Z0CG3115FG
  • 18651-95-1


Separation of Dextromethorphan hydrobromide on Newcrom R1 HPLC column

Dextromethorphan hydrobromide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Dextromethorphan hydrobromide on Newcrom R1 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

Application Analytes:

Dextromethorphan hydrobromide

HPLC Separation of NyQuil Active Ingredients on Primesep AP Column
Separation type: Liquid Chromatography HILIC View on

High Performance Liquid Chromatography (HPLC) Method for Analysis of Acetaminophen, Dextromethorphan, Pseudoephedrine, Doxylamine
Nyquil is a combination of medicines used to treat headaches, fever, body aches, cough, runny nose, sneezing, and sore throat caused by allergies, the common cold, or the flu. Nyquil contains the active ingredients acetaminophen, dextromethorphan HBr, doxylamine succinate, and sometimes, phenylephrine HCl. Acetaminophen is a pain reliever and fever reducer. Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing. Doxylamine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. All active compounds of Nyquil can be separated in HPLC on a Primesep AP mixed-mode column. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 210 nm.


Column Primesep AP, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 90-60%, 10 min
Buffer H2SO4 - 0.4%
Flow Rate 1.0 ml/min
Detection UV, 210 nm


Class of Compounds Drug, Basic, Hydrophobic, Ionizable
Analyzing Compounds Acetaminophen, Dextromethorphan, Pseudoephedrine, Doxylamine

Application Analytes:

Acetaminophen (Paracetamol)
Dextromethorphan hydrobromide
Pseudoephedrine (PSE)