Dibutylphthalate (DBP)

Dibutyl phthalate structural formula

CAS Number84-74-2
Molecular FormulaC16H22O4
Molecular Weight278.348
InChI KeyDOIRQSBPFJWKBE-UHFFFAOYSA-N
LogP4.50
Synonyms
  • Dibutyl phthalate
  • Dibutyl benzene-1,2-dicarboxylate
  • 1,2-Benzenedicarboxylic acid, dibutyl ester
  • 84-74-2
  • 1,2-Benzenedicarboxylic acid, dibutyl ester
  • Di-n-butylorthophthalate
  • DBP
  • 1,2-Benzenedicarboxylic acid dibutyl ester
  • 1,2-Benzenedicarboxylic acid, 1,2-dibutyl ester
  • Bis-n-butyl phthalate
  • Butyl phthalate
  • Celluflex DPB
  • Corflex 440
  • Di(n-butyl) 1,2-benzenedicarboxylate
  • Dibutilftalato
  • Dibutyl 1,2-benzenedicarboxylate
  • Dibutyl o-phthalate
  • DI-BUTYL PHTHALATE
  • Dibutylphthalat
  • Dibutylphthalate
  • Di-n-butyl phthalate
  • Ergoplast FDB
  • ftalato de dibutilo
  • Genoplast B
  • Hatco DBP
  • Hexaplas M/B
  • Kodaflex DBP
  • Monocizer DBP
  • n-Butyl phthalate
  • NSC 6370
  • Palatinol C
  • Phtalate de dibutyle
  • PHTHALATE, BUTYL
  • PHTHALATE, DIBUTYL
  • Phthalic acid di-n-butyl ester
  • PHTHALIC ACID, DIBUTYL ESTER
  • PHTHALSAEURE-DIBUTYLESTER
  • Plasthall DBP
  • Polycizer DBP
  • Staflex DBP
  • Unimoll DB
  • Vestinol C
  • Witcizer 300
  • o-Benzenedicarboxylic acid, dibutyl ester
  • BRN 1914064
  • N-Butylphthalate
  • Caswell No. 292
  • EINECS 201-557-4
  • EPA Pesticide Chemical Code 028001
  • Ersoplast FDA
  • Hatcol DBP
  • Phthalate, dibutyl-
  • Phthalate, di-n-butyl
  • RC Plasticizer DBP
  • RCRA waste number U069
  • Uniflex DBP
  • Di-n-butylester kyseliny ftalove
  • UNII-2286E5R2KE
  • Benzene-o-dicarboxylic acid di-n-butyl ester
  • Benzenedicarboxylic acid dibutyl ester
  • Dibutyl 1,2-benzenedicarboxylate
  • Dibutyl-o-phthalate
  • Phthalic acid dibutyl ester
  • o-Benzenedicarboxylic acid dibutyl ester

Applications:

HPLC Separation of Phthalates

November 4, 2020

HPLC Method for Diethylphthalate (DEP), Dimethylphthalate (DMP), Dipropylphthalate (DPP), Dibutylphthalate (DBP) on Newcrom A by SIELC Technologies

 

 

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Diethylphthalate (DEP), Dimethylphthalate (DMP), Dipropylphthalate (DPP), Dibutylphthalate (DBP).

Dimethyl Phthalate (DMP) is a phthalate ester with the chemical formula C10H10O4.  It has a vide variety of uses from being an ingredient in insect repellent to being a part of safety glass and goggles.  While it may appear similar to water, it is only soluble in organic solvents and not water. DMP is an irritant to eyes, nose, and throat through inhalation.

Diethyl Phthalate (DEP) is a phthalate ester with the chemical formula C10H10O4.  It is used as a solvent in perfumes, lotions, and creams. In medicine, it is used as an inactive ingredient for purposes of slowing down the release of active ingredients.

Dipropyl Phthalate (DPP) is a phthalate with the chemical formula C14H18O4.  It is used to increase the durability elasticity of plastics while also being a solvent for certain chemical applications. While it’s toxicity is low, it can still be dangerous, considering the risks of phthalates.

Dibutyl Phthalate (DBP) is a phthalate with the chemical formula C16H22O4.  It is used to increase the durability elasticity of plastics, as well as an ingredient in glues. DBP is an endocrine disruptor, which means that it effects hormone production.

Diethylphthalate (DEP), Dimethylphthalate (DMP), Dipropylphthalate (DPP), Dibutylphthalate (DBP) can be retained and analyzed using the Newcrom A stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a perchloric acid buffer. Detection is performed using UV.

Condition
Column  3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 50/50%
Buffer HClO4 – 0.1%
Flow Rate 0.5 ml/min
Detection UV, 230 nm

 

Description
Class of Compounds
 Phthalates,  Hydrophobic
Analyzing Compounds Diethylphthalate (DEP), Dimethylphthalate (DMP), Dipropylphthalate (DPP), Dibutylphthalate (DBP)

 

Application Column

Newcrom A

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Dibutylphthalate (DBP)
Diethylphthalate (DEP)
Dimethylphthalate (DMP)
Dipropylphthalate (DPP)
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Dibutyl phthalate on Newcrom R1 HPLC column

February 16, 2018
Separation of Dibutyl phthalate on Newcrom C18 HPLC column

Dibutyl phthalate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Dibutylphthalate (DBP)
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.