Dichloroacetic acid

Dichloroacetic acid structural formula

CAS Number 79-43-6
Molecular Formula C2H2Cl2O2
Molecular Weight 128.941 g/mol
InChI Key JXTHNDFMNIQAHM-UHFFFAOYSA-N
LogP 0.92
Synonyms
  • Dichloroacetic acid
  • Acetic acid, 2,2-dichloro-
  • 79-43-6
  • 4-02-00-00498
  • Acetic acid, dichloro-
  • Acetic acid, 2,2-dichloro-
  • Acide dichloroacetique
  • acido dicloroacetico
  • DCA (acid)
  • Dichloracetic acid
  • DICHLORESSIGSAEURE
  • Dichloressigsaure
  • Dichlorethanoic acid
  • Dichloroethanoic acid
  • NSC 2654
  • UN 1764
  • BRN 1098596
  • 2,2-Dichloroacetic acid
  • EINECS 201-207-0
  • Urner's liquid
  • Kyselina dichloroctova
  • UNII-9LSH52S3LQ
  • bichloracetic acid
  • 42428-47-7

Applications:


Separation of Dichloroacetic acid on Newcrom R1 HPLC column

Dichloroacetic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Dichloroacetic acid on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Dichloroacetic acid

HPLC Separation of Haloacetic acids on Newcrom BH Column
HPLC.cloud View on hplc.cloud

Condition

Column Newcrom BH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 50/50%
Buffer H2SO4 - 0.5%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Dichloroacetic acid, Trifluoroacetic acid (TFA),   Trichloroacetic acid


Application Analytes:

Dichloroacetic acid
TFA (Trifluoroacetic Acid)
Trichloroacetic acid

HPLC Separation of Acetic acid, Chloroacetic acid, Dichloroacetic acid, Trifluoroacetic acid,   Trichloroacetic acid
HPLC.cloud View on hplc.cloud Acetic acid and its substitution derivatives, chloroacetic acid, dichloroacetic acid, trichloroacetic acid, difluoroacetic acid and trifluoroacetic acid, are heavily used as building blocks for more complex compounds in organic synthesis. All six acids can be isocratically separated in HPLC using Newcrom BH mixed-mode column with acetonitrile (ACN) and water mobile phase with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.

Condition

Column Newcrom BH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 50/50%
Buffer H2SO4 - 0.2%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Acetic acid, Chloroacetic acid, Dichloroacetic acid, Trifluoroacetic acid (TFA),   Trichloroacetic acid


Application Analytes:

Acetic Acid
Chloroacetic acid
Dichloroacetic acid
Difluoroacetic acid
TFA (Trifluoroacetic Acid)
Trichloroacetic acid

HPLC Separation of Bromoacetic and Chloroacetic Acids on Newcrom BH Column
HPLC.cloud View on hplc.cloud Acetic acid and its various chloro- and bromo- forms are widely used in organic chemistry.  Their similar structure makes the acids difficult to retain and separate on reverse-phase HPLC columns.  By using Newcrom BH mixed-mode column which also has ion-exchange properties, the separation can be achieved with a simple isocratic method and relatively short time with a mobile phase of acetonitrile (ACN), water and sulfuric acid (H2SO4) buffer.  UV detection at 200nm.

Condition

Column Newcrom BH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 10/90%
Buffer H2SO4 - 0.3%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Acetic acid, Chloroacetic acid,  Bromoacetic acid, Difluoroacetic acid, Unknown, Dichloroacetic acid, Bromochloroacetic acid, Dibromoacetic acid


Application Analytes:

Acetic Acid
Bromoacetic acid
Bromochloroacetic acid
Chloroacetic acid
Dibromoacetic acid
Dichloroacetic acid
Difluoroacetic acid

HPLC Separation of Bromoacetic and Chloroacetic acids on Newcrom B Column
HPLC.cloud View on hplc.cloud Bromo- and chloro- acetic acids are widely used in organic chemistry.  Their similar structure makes the acids difficult to retain and separate on reverse-phase HPLC columns.  By using Newcrom BH mixed-mode column which also has ion-exchange properties, the separation can be achieved with a simple isocratic method and relatively short time with a mobile phase of acetonitrile (ACN), water and sulfuric acid (H2SO4) buffer.

Condition

Column Newcrom B, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 10/90%
Buffer AmFm pH 3.0
Flow Rate 1.0 ml/min
Detection CAD

Description

Class of Compounds Acid
Analyzing Compounds Bromoacetic acid, Dichloroacetic acid,  Dibromoacetic acid


Application Analytes:

Bromoacetic acid
Dibromoacetic acid
Dichloroacetic acid
Trichloroacetic acid