Docusate sodium

CAS Number 577-11-7
Molecular Formula C20H37NaO7S
Molecular Weight 444.560 g/mol
InChI Key APSBXTVYXVQYAB-UHFFFAOYSA-M
LogP 4.32
Synonyms
  • Docusate sodium
  • Aerosol OT
  • Colace
  • DEH Na SS
  • DEH-Na-SS
  • diethylhexyl sodium sulfosuccinate
  • Dioctyl Sulfosuccinate
  • Dioctyl Sulfosuccinate, Sodium
  • Dioctyl Sulfosuccinates
  • Dioctyl Sulfosuccinic Acid
  • Dioctyl Sulfosuccinic Acid, Ammonium Salt
  • Dioctyl Sulfosuccinic Acid, Barium Salt
  • Dioctyl Sulfosuccinic Acid, Calcium Salt
  • Dioctyl Sulfosuccinic Acid, Magnesium Salt
  • Dioctyl Sulfosuccinic Acid, Potassium Salt
  • Dioctyl Sulfosuccinic Acid, Sodium Salt
  • Dioctylsulfosuccinate
  • Dioctylsulphosuccinate, Sodium
  • Docusate
  • Docusate Calcium
  • Docusate Potassium
  • Docusate Sodium
  • DOSS
  • Sodium Bis(2-ethylhexyl)sulfosuccinate
  • Sodium Dioctyl Sulfosuccinate
  • Sodium Dioctylsulphosuccinate
  • Sodium Sulfosuccinate, Diethylhexyl
  • Sulfosuccinate, Diethylhexyl Sodium
  • Sulfosuccinate, Dioctyl
  • Sulfosuccinates, Dioctyl
  • Sulfosuccinic Acid bis(2-Ethylhexyl) Ester
  • Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
  • Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
  • 577-11-7
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • Bis(2-ethylhexyl) sodium sulfosuccinate
  • Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt
  • 1,4-Bis(2-ethylhexyl) sodium sulfosuccinate
  • 1,4-BIS(2-ETHYLHEXYL)SULFOSUCCINIC ACID SODIUM SALT
  • Acrosol OT 100
  • Adekacol EC 4500
  • Adekacol EC 8600
  • Aerosol A 501
  • Aerosol AOT
  • Aerosol GPG
  • Aerosol OT
  • Aerosol OT 100
  • Aerosol OT 70
  • Aerosol OT 70PG
  • Aerosol OT 75
  • Aerosol OT 75E
  • Aerosol OT 75PG
  • Aerosol OT 94
  • Aerosol OT-A
  • Aerosol OT-B
  • Aerosol OT-S
  • Airrol CT 1
  • Airrol CT 1L
  • Airrol OP
  • Alcopol O
  • Alkasurf SS-O 75
  • Alphasol OT
  • Astrowet 608
  • Astrowet O 70PG
  • Astrowet O 75
  • Bis(2-ethylhexyl) sodiosulfosuccinate
  • Bis(2-ethylhexyl) S-sodium sulfosuccinate
  • Bis(2-ethylhexyl) sulfosuccinate sodium salt
  • Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl)ester, sodium salt
  • BUTANEDIOIC ACID, SULFO-, BIS-2-ETHYLHEXYL ESTER, SODIUM SALT
  • BUTANEDIOIC ACID, SULFO-,1,4-BIS(2-ETHYLHEXYL) ESTER, SODIUM SALT
  • Butanedioic acid, sulfo-1,4-bis(2-ethylhexyl) este-r, sodium salt
  • Carabon DA 72
  • Celanol DOS 65
  • Celanol DOS 75
  • Chemax DOSS 70PG
  • Comfolax
  • Complemix
  • Constonate
  • Coprola
  • Correctol Stool Softener Laxative
  • Defilin
  • Di(2-ethylhexyl) sulfosuccinate sodium salt
  • Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
  • Di-2-ethylhexyl sodium sulfosuccinate
  • DI-2-ETHYLHEXYL SULFOSUCCINIC ACID SODIUM SALT
  • Dialose
  • Dioctlyn
  • Dioctyl
  • Dioctyl sulfosuccinate sodium
  • Dioctyl sulfosuccinate sodium salt
  • Dioctylal
  • Dioctyl-Medo Forte
  • DioctylSodium Sulfosuccinate
  • Diomedicone
  • Diosuccin
  • Diotilan
  • Disonate
  • Disposaject
  • Docusate sodique
  • Docusatnatrium
  • docusato sodico
  • Doxinate
  • Drewfax 007
  • Dulcivac
  • Dulsivac
  • Empimin OP 70
  • Empimin OT 75
  • Freetex OT
  • Gemtex SC
  • Gemtex SC 40
  • Genopur SB 1970J
  • Geropon DOS
  • Geropon SS-O 75
  • Geropon WT 27
  • Humifen WT 27G
  • Isoprotanc
  • Karawet DOSS
  • Koremul 290
  • Lankropol 4500
  • Lankropol KO 2
  • Laxinate
  • Lumiten I-RA
  • Lutensit A-BO
  • Lutensit A-BOS
  • Mackanate DOS 75
  • Manoxol
  • Manoxol OP
  • Manoxol OT
  • Marlinat DF 8
  • Mervamine
  • Miconate DOS
  • Modane Soft
  • Molatoc
  • Molofac
  • Monawet M 085P
  • Monawet MO 65-150
  • Monawet MO 70
  • Monawet MO 70E
  • Monawet MO 70R
  • Monowet MO 70R
  • Monowet MO-E 75
  • Neocol P
  • Neocol YSK
  • Neopelex OTP
  • Newcol 290M
  • Newcol 291EG
  • Newcol 291M
  • Newcol 291PG
  • Newkalgen EP 60P
  • Newkalgen EP 70G
  • Nikkol OTP 100
  • Nikkol OTP 100S
  • Nikkol OTP 70
  • Nikkol OTP 75
  • Nissan Rapisol
  • Nissan Rapisol A 30
  • Nissan Rapisol A 80
  • Nissan Rapisol A 90
  • Nissan Rapisol B 07
  • Nissan Rapisol B 30
  • Nissan Rapisol B 80
  • Nissan Rapisol B 90
  • Octowet
  • Pelex OT
  • Pelex OT-P
  • Persol KMN 3
  • Pionin A 51B
  • Rapisol
  • Rapisol A 30
  • Rapisol A 80
  • Rapisol A 90
  • Rapisol B 30
  • Rapisol B 80
  • Rapisol B 90
  • Regutol
  • Rewopol SBDO 70
  • Rikakoru M 75
  • Sanmorin OT
  • Sanmorin OT 70
  • Sanmorin OT 70N
  • Sanseparer 100
  • Secosol DOS 70
  • SN-Wet OT 70
  • Sobital
  • Sodium 1,2-bis(2-ethylhexyloxycarbonyl)-1-ethanesulfonate
  • Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate
  • Sodium bis(2-ethylhexyl) sulfosuccinate
  • Sodium bis(ethylhexyl) sulfosuccinate
  • Sodium di(2-ethylhexyl) sulfosuccinate
  • Sodium di(ethylhexyl) sulfosuccinate
  • sodium dioctyl sulfosuccinate aerosol ot 75 sponto ha
  • Sodium docusate
  • Soliwax
  • Solovet
  • Solusol
  • Succinate STD
  • Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • SUCCINIC ACID, SULFO-, 1,4-BIS(2-ETHYLHEXYL) ESTERSODIUM SALT
  • Sulfimel DOS
  • SULFOBERNSTEINSAEURE-1,4-BIS-(2-AETHYLHEXYL)-ESTER-NA-SALZ
  • Sulfobutanedioic acid 1,4-bis(2-ethylhexyl)ester sodium salt
  • Sulfobutanedioic acid, 1,4-bis(2-ethylhexyl) ester, sodium salt
  • SULFOSUCCINATE, 2-ETHYLHEXYL, SODIUM
  • Sulfosuccinic acid bis(2-ethylhexyl)ester sodium salt
  • Sulfosuccinic acid di-2-ethylhexyl ester sodium salt
  • Sunnol LDF 110
  • Surfonic DOS 75PG
  • Talosurf
  • Tex-Wet 1001
  • Triton GR 5
  • Triton GR 5M
  • Triton GR 7
  • Triton GR 7M
  • Triton GR 7ME
  • Vatsol OT
  • Warcowet 060
  • Wetaid SR
  • Bis(ethylhexyl) ester of sodium sulfosuccinic acid
  • Bis(2-ethylhexyl)sodium sulfosuccinate
  • Clestol
  • Dioctyl ester of sodium sulfosuccinate
  • Dioctyl ester of sodium sulfosuccinic acid
  • EINECS 209-406-4
  • 2-Ethylhexyl sulfosuccinate sodium
  • Laxinate 100
  • Manoxal OT
  • Monawet MD 70E
  • Monawet MO-70
  • Monawet MO-84 R2W
  • Monawet MO-70 RP
  • Monoxol OT
  • Natrii dioctylsulfosuccinas
  • Nekal WT-27
  • Requtol
  • Sodium dioctyl sulphosuccinate
  • Sodium 2-ethylhexylsulfosuccinate
  • Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate
  • Solusol-100%
  • Solusol-75%
  • Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt
  • Triton GR-5
  • Coloxyl
  • Bis-2-ethylhexylester sulfojantaranu sodneho
  • Docusatum natricum
  • Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego
  • Dioctyl sodium sulphosuccinat
  • UNII-F05Q2T2JA0
  • Bloat treatment
  • Docuprene
  • Docolace
  • Doc Q Lace
  • 105956-73-8
  • 106396-28-5
  • 110162-65-7
  • 113255-61-1
  • 12640-70-9
  • 130390-93-1
  • 133136-80-8
  • 135843-72-0
  • 138893-51-3
  • 141092-35-5
  • 154608-80-7
  • 201816-76-4
  • 202352-75-8
  • 209122-63-4
  • 209453-97-4
  • 29732-38-5
  • 336190-18-2
  • 51910-13-5
  • 52624-44-9
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  • 56833-49-9
  • 59030-04-5
  • 60202-21-3
  • 66812-62-2
  • 67924-68-9
  • 75418-10-9
  • 76689-26-4
  • 78207-03-1
  • 835616-33-6
  • 590366-27-1
  • 1420177-77-0
  • 1644530-78-8

Applications:


HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid
Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent.  It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.   Application Columns: Primesep B4   Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid Detection technique: LC/MS, ELSD/CAD

Condition

Column Primesep B4, 3.2x50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10 -50%, 10 min
Buffer Gradient AmFm pH 3.0- 60-180 mM, 10 min
Flow Rate 1.0 ml/min
Detection ELSD
 

Description

Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid
 

Application Analytes:

Dioctyl sulfosuccinic acid
Docusate sodium
Sodium
Sulfosuccinic acid

Separation of Docusate sodium on Newcrom R1 HPLC column

Docusate sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Docusate sodium on Newcrom R1 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Docusate sodium

HPLC Determination of Docusate Sodium in Softgels on Newcrom BH Column
Separation type: Liquid Chromatography Mixed-mode

HPLC.cloud View on hplc.cloud



High Performance Liquid Chromatography (HPLC) Method for Analysis of Docusate.

Docusate is used as a laxative and stool softener. Docusate retains water in the stool, thereby acting as a stool softener to facilitate stool passage. Docusate can be retained on the Newcrom BH mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 200 nm.

Condition

Column Newcrom BH, 3.2x100 mm, 3 µm, 100A
Mobile Phase MeCN/H2O -75/25%
Buffer  H2SO4 - 0.5%
Flow Rate 0.5 ml/min
Detection UV, 200 nm
 

Description

Class of Compounds Drug
Analyzing Compounds Docusate Sodium
 

Application Analytes:

Dioctyl sulfosuccinic acid
Docusate sodium