Fenofibrate

Fenofibrate structural formula

CAS Number49562-28-9
Molecular FormulaC20H21ClO4
Molecular Weight360.830
InChI KeyYMTINGFKWWXKFG-UHFFFAOYSA-N
LogP4.71
Synonyms
  • Fenofibrate
  • Propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
  • Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester
  • 49562-28-9
  • Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester
  • 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester
  • Ankebin
  • Clorofibrate
  • Elasterin
  • Fenobrate
  • Fenofibrat
  • fenofibrato
  • Fenogal
  • Fenotard
  • Isopropyl 2-[p-(p-chlorobenzoyl)phenoxy]-2-methylpropionate
  • Lipanthyl
  • Lipantil
  • Lipicard
  • Lipidil
  • Lipidil Supra
  • Lipirex
  • Lipoclar
  • Lipofene
  • Liposit
  • MeltDose
  • Nolipax
  • NSC 281319
  • Procetofen
  • Procetofene
  • Procetoken
  • Protolipan
  • Secalip
  • BRN 2062462
  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
  • EINECS 256-376-3
  • Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
  • Lipidex
  • Lipifen
  • Proctofene
  • Sedufen
  • Elasterate
  • Luxacor
  • Triglide
  • Lipofen
  • Fenoglide
  • Fenofibratum
  • UNII-U202363UOS
  • FNF
  • Finofibrate
  • Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
  • Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
  • Lipantil (TN)
  • Tricor (TN)

Applications:

HPLC Separation of Fenofibric Acid and Fenofibrate on Primesep 100 Column

September 1, 2021

Separation type: Liquid Chromatography Mixed-mode

 

Condition 1

Column Primesep 100, 2.1×100 mm, 2.7 µm, 100A
Mobile Phase MeCN – 60%
Buffer Formic Acid  – 0.05%
Flow Rate 0.2 ml/min
Detection UV, 286 nm

Condition 2

Column Newcrom AH, 3.2×100 mm, 3 µm, 100A
Mobile Phase MeCN – 45%
Buffer Formic Acid  – 0.05%
Flow Rate 0.5 ml/min
Detection UV, 286 nm

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable, Supplements
Analyzing Compounds Fenofibrate, Fenofibric Acid

Application Column

Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Fenofibrate
Fenofibric acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Fenofibric Acid and Fenofibrate on Primesep 200 column

May 10, 2016

 

Fenofibrate is a synthetic Peroxisome Proliferator Receptor alpha (PPAR alpha) Agonist as well as an antilipemic agent. It is used to help lower “bad” cholesterol and fats (LDL, triglycerides) by increasing the natural enzyme that breaks down fats in the blood. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Propranolol. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

 

Condition

Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN – 45%
Buffer H2SO4 – 0.05%,
Flow Rate 0.5 ml/min
Detection UV, 286 nm

 

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable, Supplements
Analyzing Compounds Fenofibrate

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Fenofibrate

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.