Fosfomycin

CAS Number 23155-02-4
Molecular Formula C3H7O4P
Molecular Weight 138.060 g/mol
InChI Key YMDXZJFXQJVXBF-STHAYSLISA-N
LogP -1.91
Synonyms
  • Fosfomycin
  • [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid
  • Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-
  • 23155-02-4
  • Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-
  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
  • (-)-(cis-1,2-Epoxypropyl)phosphonic acid
  • (-)-Phosphonomycin
  • (2R-cis)-(3-Methyloxiranyl)phosphonic acid
  • [(2R,3S)-3-Methyloxiranyl]phosphonic acid
  • Antibiotic 833A
  • Fosfocina
  • Fosfomicin
  • fosfomicina
  • fosfomycine
  • Fosfonomycin
  • Infectophos
  • Levo-phosphonomycin
  • Phosphomycin
  • Phosphonic acid, (1,2-epoxypropyl)-, (1R,2S)-(-)-
  • Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-
  • Phosphonic acid, P-[(2R,3S)-3-methyl-2-oxiranyl]-
  • Phosphonomycin
  • BRN 1680831
  • EINECS 245-463-1
  • Fosfomycinum
  • UNII-2N81MY12TE
  • (1R,2S)-epoxypropylphosphonic acid
  • 1R-cis-(1,2-epoxypropyl)phosphonic acid
  • FCM
  • L-cis-1,2-epoxypropylphosphonic acid
  • cis-(1R,2S)-epoxypropylphosphonic acid
  • phosphonemycin

Applications:


Separation of Fosfomycin on Newcrom R1 HPLC column

Fosfomycin can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Fosfomycin on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Fosfomycin

HPLC Determination of Fosfomycin on Primesep SB Column
HPLC Determination of Fosfomycin
Fosfomycin is a broad-spectrum antibiotic consisting of an epoxide ring and a phosphite group. It can be retained on a Primesep SB column in about 8 minutes using an isocratic MS-compatible mobile phase method. Primesep SB is a reverse-phase (RP) mixed-mode column with embedded strong basic ion-pairing groups.
 

Condition

Column Primesep SB, 3.2x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer AmFm pH 3.0- 20 mM
Flow Rate 0.5 ml/min
Detection CAD (Corona) MS- compatible mobile phase
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Antibiotic
Analyzing Compounds Fosfomycin
 

Application Analytes:

Fosfomycin