Gabapentin hydrochloride

Gabapentin hydrochloride structural formula

CAS Number60142-95-2
Molecular FormulaC9H18ClNO2
Molecular Weight207.700
InChI KeyXBUDZAQEMFGLEU-UHFFFAOYSA-N
LogP0.0332
Synonyms
  • Gabapentin hydrochloride
  • [1-(Aminomethyl)cyclohexyl]acetic acid--hydrogen chloride (1/1)
  • Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1)
  • 60142-95-2
  • EINECS 262-075-8
  • 1-(Aminomethyl)cyclohexaneacetic acid HCl
  • UNII-N0PY5N5AFW

Applications:

HPLC Determination of Gamma-aminobutyric Acid (GABA), Gabapentin and Pregabalin on Primesep N Column

June 8, 2021

Separation type: Liquid Chromatography Mixed-mode





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High Performance Liquid Chromatography (HPLC) Method for Analysis of GABA, Gabapentin and Pregabalin



Condition

Column Primesep N,  4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmFm pH 3.0 – 10 mM
Flow Rate 1.0  ml/min
Detection CAD (Corona)  (MS-compatible mobile phase)

 

Description

Class of Compounds
Acid, Drug
Analyzing Compounds  Gamma-Aminobutyric acid (GABA), Gabapentin, Pregabalin

Application Column

Primesep N

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Gabapentin
Gabapentin hydrochloride
Pregabalin
gamma-Aminobutyric Acid (GABA)
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Gabapentin Tablets

June 11, 2018

HPLC Method for Analysis of Gabapentin Tablets
Gabapentin is a drug used to treat epilepsy, neuropathic pain, hot flashes, and restless legs syndrome. It also is used to treat neuropathic pain. Gabapentin can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It is also suitable for pharmacokinetics.

Condition 1

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer AmFm pH 3.0 – 30 mM
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

 

Condition 2

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 50/50%
Buffer H2SO4 – 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 210 nm

Description

Class of Compounds
Drug,  Nerve pain medication, Anticonvulsant, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds Gabapentin

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Gabapentin
Gabapentin hydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.