Glycolic acid

Glycolic acid sodium salt structural formula

CAS Number2836-32-0
Molecular FormulaC2H3NaO3
Molecular Weight98.033
InChI KeyVILMUCRZVVVJCA-UHFFFAOYSA-M
LogP-1.91
Synonyms
  • Glycolic acid sodium salt
  • Sodium hydroxyacetate
  • Acetic acid, 2-hydroxy-, sodium salt (1:1)
  • 2836-32-0
  • Sodium glycolate
  • Acetic acid, hydroxy-, monosodium salt
  • Acetic acid, 2-hydroxy-, sodium salt (1:1)
  • ACETIC ACID, HYDROXY-MONOSODIUM SALT
  • glicolato de sodio
  • Glycolate de sodium
  • GLYCOLATE, SODIUM
  • Glycolic acid, monosodium salt
  • Hydroxyacetic acid sodium salt
  • Hydroxyacetic acid, monosodium salt
  • Natriumglykolat
  • sodium glycollate
  • Sodium hydroxyacetate
  • Sodium ?-hydroxyacetate
  • EINECS 220-624-9
  • Glykokolan sodny
  • UNII-B75E535IMI
  • Glycolic acid, sodium salt
  • Monosodium glycolate
  • Sodium 2-hydroxyacetate
  • Sodium lycolate

Applications:

HPLC Method for Analysis of Dicarbon Carboxylic Acids on Newcrom BH Column

June 6, 2023

HPLC Method for Analysis of Oxalic Acid, Glycolic acid, Acetic Acid, Glyoxylic acid on Newcrom BH by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Analysis of Dicarbon Carboxylic Acids by on Newcrom BH Column SIELC Technologies
  1. Glyoxylic Acid (CHO-COOH): This is the smallest α-keto acid. It is a yellowish solid that occurs naturally and is useful industrially. It participates in many biochemical reactions. Its reduced form, D-lactic acid, can be found in various microorganisms.
  2. Glycolic Acid (HOCH2COOH): This is the smallest α-hydroxy acid (AHA). It’s derived from sugar cane and is a colorless, odorless, and hygroscopic crystalline solid. It is used in various skin-care products because of its capability to penetrate skin.
  3. Acetic Acid (CH3COOH): It is a simple carboxylic acid. It’s an important chemical reagent and industrial chemical, primarily used in the production of cellulose acetate for photographic film and polyvinyl acetate for wood glue, as well as synthetic fibers and fabrics. It gives vinegar its sour taste and pungent smell.
  4. Oxalic Acid (C2H2O4): This is a colorless crystalline solid that forms a colorless solution in water. It occurs naturally in many foods, but too much can lead to kidney stones. It’s used in many different industrial processes, including rust removal, bleaching, and as a reducing agent in developing photographic film.

These four acids be separate and analyzed on a reverse-phase Newcrom BH, 4.6 x 150 mm, 3 µm, 100 A column with a mobile phase consisting of water and perchloric acid as a buffer modifier. This analysis method can be UV detected at 200 nm.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Oxalic Acid, Glycolic acid, Acetic Acid, Glyoxylic acid

Condition

ColumnNewcrom BH, 4.6 x 150 mm, 3 µm, 100 A
Mobile PhaseH2O -99.7%
BufferHClO4 – 0.3
Flow Rate1.0 ml/min
DetectionUV 200 nm

Description

Class of CompoundsDicarbon Carboxylic Acids
Analyzing CompoundsOxalic Acid, Glycolic acid, Acetic Acid, Glyoxylic acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A

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Application Analytes:
Acetic Acid
Glycolic acid
Glyoxylic acid
Oxalic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Small Organic Acids on Newcrom B Column

October 22, 2019


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Condition

Column Newcrom B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 5/95%
Buffer AmAc pH 5.0, Formic Acid
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

Description

Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Glycolic acid, Succinic Acid, Methylmalonic acid, Malic Acid, Maleic Acid, Citric Acid, Tartaric Acid, Fumaric Acid, Malonic Acid

Application Column

Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Citric Acid
Fumaric Acid
Gluconic acid
Glycolic acid
Maleic Acid
Malic Acid
Malonic Acid
Methylmalonic Acid
Succinic Acid
Tartaric Acid
dl-Tartaric acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Glycolic acid sodium salt on Newcrom R1 HPLC column

February 16, 2018
Separation of Glycolic acid sodium salt on Newcrom C18 HPLC column

Glycolic acid sodium salt can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Glycolic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.