HPLC Determination of Sodium Dodecyl Sulfate on Newcrom AH Column

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      Sodium dodecyl sulfate, or sodium lauryl sulfate, is a surfactant used in cleaning and hygienic products. It has a twelve carbon hydrophobic tail attached to a polar sulfate. Dodecyl sulfate can be retained on Primesep B4 column in under 5 minutes with an MS-compatible mobile phase. Primesep B4 is a short carbon chain reverse-phase (RP) mixed-mode column with embedded basic ion-pairing groups.


Column Newcrom AH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 40/60%
Buffer AmFm pH 3.0 - 20 mM
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase


Class of Compounds Hydrophobic, Base, Ionizable, Anionic surfactant
Analyzing Compounds Sodium Dodecyl Sulfate

Application Analytes:

Sodium dodecyl sulfate