| Column | Primesep S, Primesep 500 4.6×150 mm, 5 µm, 100Å |
| Mobile Phase | MeCN – 100% |
| Flow Rate | 1.0 ml/min |
| Detection | CAD (Corona) MS- compatible mobile phase |
| Class of Compounds |
Antibiotic, Non- charged polar molecule |
| Analyzing Compounds | Taurolidine |
Taurolidine is important medication used primarily as an antimicrobial agent in the prevention of bacterial infections in catheters. It has also been shown to have some anti-tumor properties.
Taurolidine is not approved for use in the United States, but widely used in the rest of the world.
HPLC analysis of taurolidine in reverse-phased mode poses a challenge with mobile phases that contain water. It undergoes hydrolysis when exposed to water and therefore requires pure organic mobile phase. We developed a simple method based on our mixed-mode column technology. Interesting that varying retention times, based on the molecular structure of ligand, can be achieved in pure bufferless acetonitrile (ACN) mobile phase using Sielc’s mixed-mode Primesep columns.
Application Column
Primesep S
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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Primesep 500
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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Primesep C
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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